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科学家 Kathleen Gould (细胞生物学)

上一篇 / 下一篇  2010-07-22 14:17:12

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科研学术生涯:

http://f1000biology.com/about/biography/439926051458668

研究团队与实验室

http://www.mc.vanderbilt.edu/vumcdept/cellbio/gould/

发表的论文与研究成果:

http://www.mc.vanderbilt.edu/vumcdept/cellbio/gould/Pubs.html

since 2006

 

Bohnert, K.A., Chen, J.-S., Clifford, D.M., VanderKooi, C.W. and Gould, K.L. (2009) A Link between Aurora Kinase and Clp1/Cdc14 Regulation Uncovered by the Identification of a Fission Yeast Borealin-like Protein.Mol. Biol.Cell, 20, 3646-3659.

 

Roberts-Galbraith, R.H., Chen, J.-S., Wang, J., and Gould, K.L. (2009) The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.J. Cell. Biol.184(1):113-127

 

Roberts-Galbraith, R.H. and Gould, K.L. (2008) Stepping into the ring: the SIN takes on contractile ring assembly.Genes Dev.22(22):3205-3216

 

Chen, C.T., Feoktistova, A., Chen, J.-S., Shim, Y.S., Clifford, D.M., Gould, K.L., and McCollum, D., (2008) The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.Current Biol.18(20):1594-1599

 

Sczaniecka, M., Feoktistova, A., May, K.M., Chen, J.-S., Blyth, J., Gould, K.L., and Hardwick, K.G. The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).J. Biol. Chem.283(34): 23039-47.

 

Clifford, D.M., Chen, C.T., Roberts-Galbraith, R.H., Feoktistova, A., Wolfe, B.A., Chen, J.-S., McCollum, D., Gould, K.L. (2008) The role of Cdc14 phosphatases in the control of cell division.Biochem. Soc. Trans.36(Pt 3):436-8

 

Clifford, D.M., Wolfe, B.A., Roberts-Galbraith, R.H., McDonald, W.H., Yates, J.R., Gould, K.L. (2008) The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.J Cell Biol.181(1):79-88

 

Ohi, M.D., Feoktistiva, A., Ren, L., Yip, C., Cheng, Y., Chen J.-S., Yoon, H.J., Wall, J.S., Huang, Z., Penczek, P.A., Gould, K.L. and Walz, T. Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.Mol Cell.2007 Dec 14;28(5):871-85.

 

Ohi, M.D., Ren, L., Wall, J.S., Gould, K.L., and Walz, T. (2007) Structural characterization of the fission yeast U5U2/U6 spliceosome complex.PNAS USA104(9):3195-3200

 

Yoon, H.-J., Feoktistova, A., Wolfe, B. A., Jennings, J.L., Link, A.J., and Gould, K.L. (2006) Role of Hcn1 and its phosphorylation in fission yeast APC/C function.J. Biol. Chem.281(43):32284-93

 

Wolfe, B.A., McDonald, W.H., Yates, Jr., J.R., and Gould, K.L. (2006) Phosphorylation-dependent regulation of the Cdc14/Clp1 phosphatase delays mitotic events inS. pombe.Dev.Cell11:423-430

 

Rosenberg, J.A., Tomlin, G.C., McDonald, W.H., Snydsman, B.E., Muller, E.G., Yates, J.R. 3rd, Gould, K.L. (2006) Ppc89 Links Multiple Proteins, Including the Septation Initiation Network, to the Core of the Fission Yeast Spindle-Pole Body.Mol. Biol.Cell17(9):3793-805

 

Mehta, S. and Gould, K.L. (2006) Identification of functional domains within the SIN kinase Cdc7.J. Biol. Chem.281(15):9935-41

 

Vander Kooi, C.W., Ohi, M.D., Rosenberg, J.A., Oldham, M.L., Newcomer, M.E., Gould, K.L., Chazin, W.J. (2006) The Prp19 U-box Crystal Structure Suggests a Common Dimeric Architecture for a Class of Oligomeric E3 Ubiquitin Ligases.Biochemistry45(1):121-130

 

部分名著与科研绩效:

KBurridge, K Fath, T Kelly, G Nuckolls, … - Annual review of cell …, 1988 - Annual Reviews分析测试百科网TP(G)^;U~8`'n
...the Extracellular Matrix and the CytoskeletonKeithBurridge, Karl Fath, Thomas Kelly, Glen
y-j)nV4~0Nuckolls, and Christopher Turner Department of Cell Biology and Anatomy, CB # 7090, 108 Swing分析测试百科网E[#K\"rDW
Building, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599...分析测试百科网Jy%G"L'U1Z
Cited by 1838-Related articles-All 4 versions

 

ucsd.edu[PDF]AJ Ridley, MA Schwartz, KBurridge, RA Firtel, MH … - Science, 2003 - sciencemag.org分析测试百科网y vyK1s!y a}n
1 Ludwig Institute for Cancer Research, Royal Free and University College School of分析测试百科网Jp W'V'^}|
Medicine, London W1W 7BS, UK. 2 Departments of Microbiology and Biomedical分析测试百科网P8nSz"@M/A&| r*x
Engineering, Cardiovascular Research Center and Mellon Prostate Cancer Research...分析测试百科网5hU|5Z*^K i
Cited by 1370-Related articles-BL Direct-All 16 versions

 

A Horwitz, K Duggan, C Buck, MC Beckerle, KBurridge- 1986 - nature.com分析测试百科网j$xG"_8y@/G
Many observations suggest the presence of transmembrane linkages between the cytoskeleton分析测试百科网T,Fx,J/_[K
and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal
e;tH@;jsZ0a co-alignment between actin filaments at the cell surface and extracellular fibronectin...分析测试百科网pT"@/tvq&E+wl'Q
Cited by 892-Related articles-All 4 versions

 

rupress.org[PDF]M Chrzanowska-Wodnicka, KBurridge- The Journal of cell biology, 1996 - jcb.rupress.org
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Abstract. Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress分析测试百科网k E3y dF\ KO
fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, AJ, and A.
2U |*m}k6X3`"z0Hall, 1992. Cell. 70:389-399). The pathway by which rho triggers these events has not...分析测试百科网.Z4in-g'R5d t.k#xW
Cited by 864-Related articles-All 7 versions

 

rupress.org[PDF]KBurridge, CE Turner, LH Romer - Journal of Cell Biology, 1992 - jcb.rupress.org
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Abstract. Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal
6L(NV/C@0adhesions, the regions where cells adhere to the underlying substra- tum. We have examined分析测试百科网4BD8?'yT w s
the tyrosine phosphorylation of proteins in response to plating cells on extracellular matrix...
UXY _k(@C/W,F0Cited by 784-Related articles-BL Direct-All 5 versions

 

utoronto.ca[PDF]KBurridge, K Wennerberg - Cell, 2004 - Elsevier分析测试百科网 H El Ft
Many features of cell behavior. are regulated by Rho family GTPases, but the most profound effects分析测试百科网 M(iM RI
of these proteins are on the actin cytoskeleton and it was these that first drew attention to this
L:xz/T.pMCs2ra0family of signaling proteins. Focusing on Rho and Rac, we will discuss how their effectors...
X]pT'Td0Cited by 661-Related articles-All 23 versions

 

SM Schoenwaelder, KBurridge- Current opinion in cell biology, 1999 - Elsevier
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276 Cell regulation bind Cdc42 [31*]. This targeting does require PAK binding to PIX (PAK interacting
$OJ4W iX3H/a9G0exchange factor), a GEF for Rac [32*]. This suggests that there is a complex formed between分析测试百科网8bE9b+p x\
Rac or Cdc42; PAK (a downstream effector) and PIX (an upstream GEF). Mutations that...分析测试百科网;vj8V,H#wm L
Cited by 599-Related articles-BL Direct-All 3 versions

 

rupress.org[PDF]CA Otey, FM Pavalko, KBurridge- Journal of Cell Biology, 1990 - jcb.rupress.org分析测试百科网eQ4~/`9V
Abstract. A number of cytoskeletal-associated pro- teins that are concentrated in focal分析测试百科网3P'@8LXL6n
contacts, namely ot-actinin, vinculin, talin, and integrin, have been shown to interact in vitro such分析测试百科网'L4H"Y;O4Hh}
that they suggest a potential link between actin filaments and the mem- brane. Because...
W|5NKMu0Cited by 564-Related articles-All 4 versions

 

E Lazarides, KBurridge- Cell, 1975 - Elsevier分析测试百科网Oq%HR;n]FXG
Antibodies specific for the skeletal muscle structural protein α-actinin are used to localize this分析测试百科网2~9B6s5N!iNP
protein by indirect immunofluorescence in nonmuscle cells. In cultured nonmuscle cells, α-actinin分析测试百科网 gF^ p&G!Hz`J1k3_
is localized along or between actin filament bundles producing an almost regular...
;`0h)JM4^A/s0Cited by 443-Related articles-All 6 versions

 

rupress.org[PDF]CE Turner, JR Glenney Jr, KBurridge- Journal of Cell Biology, 1990 - jcb.rupress.org
7Y`_,O l5[KES0
Abstract. The 68-kD protein (paxillin) is a cytoskele- tal component that localizes to the focal adhesions分析测试百科网$yrO*n ep8I
at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal adhesions分析测试百科网3J7mi_ c#l
of Madin-Darby bovine kidney (MDBK) epithelial cells but is absent, like talin, from the...
,bG!H,Q r3x ~0Cited by 407-Related articles-All 5 versions分析测试百科网&E.VP1V7P!mP[

l e'DB?/|+cZ+pQ4n0分析测试百科网g'l N/W4PU5i

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