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科学家 Michael A Marletta (生物化学)

上一篇 / 下一篇  2010-07-22 14:19:06 / 个人分类:基本实验技术

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http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=marlettam

Michael Marletta

Aldo DeBenedictis Distinguished Professor of Chemistry and Professor of Biochemistry and Molecular Biology

Lab Homepage:http://www.cchem.berkeley.edu/mmargrp/

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Research Interests

Research in this laboratory is focused on structure/function relationships in proteins with a particular emphasis on the catalytic and biological properties of enzymes and signaling proteins. Current emphasis is on nitric oxide signaling (including studies on nitric oxide synthase, guanylate cyclase and S-nitrosation mechanisms), oxygen sensing, pathogen responses to nitric oxide, and enzymology of biofuel utilization.

 

 

Michael A Marletta分析测试百科网LdW]Y
Department of Chemistry, University of California, Berkeley, USA


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Head of Section:Chemical Biology > Bioinorganic Chemistry [ since 7 February 2005 ]
[Homepage]
Home page
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http://mcb.berkeley.edu/faculty/BMB/marlettam.html

最新研究成果:

Carlson, H.K., Plate, L., Price, M.S., Allen, J.J., Shokat, K.M., and Marletta, M.A. (2010).  Use of a semisynthetic epitope to probe histidine Kinase activity and regulation. Anal. Biochem.397: 139-143.

Weinert, E.E., Plate, L., Whited, C.A., Olea, C. Jr, and Marletta, M.A. (2010). Determinants of ligand affinity and heme reactivity in H-NOX domains. Angew. Chem. Int. Ed. Engl.49: 720-723. 

Olea, C. Jr, Herzik, M.A. Jr, Kuriyan, J., and Marletta, M.A. (2010). Structural insights into the molecular mechanism of H-NOX activation. Protein Science19: 881-887. 

Woodward, J.J., Nejatyjahromy, Y., Britt, R.D., and Marletta, M.A.  (2010). Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase.J. Amer. Chem. Soc.132: 5105-5113.

Wang, Y., Dufour, Y.S., Carlson, H.K.,Donohue, T.J., Marletta, M.A., and Ruby, E.G. (2010). H-NOX-mediated NO sensing modulates symbiotic colonization byVibrio fischeriProc. Natl. Acad. Sci. USA107: 8375-8380.

Derbyshire, E.R., Fernhoff, N.B., Deng, S. and Marletta, M. A. (2009). Nucleotide regulation of soluble guanylate cyclase substrate specificity. Biochemistry48: 7519-7524.

Agapie, T., Suseno, S., Woodward, J.J., Stoll, S., Britt, R.D., and Marletta, M.A. (2009). NO Formation by a Protein fromSorangium cellulosum: A Catalytically Self-Sufficient Bacterial Nitric Oxide Synthase. Proc. Natl. Acad. Sci. USA106: 16221-16226. 

Fernhoff, N.B., Derbyshire, E.R. and Marletta, M.A. (2009). A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc. Natl. Acad. Sci. USA106: 21602-22607.

Erbil, W.K., Price, M.S., Wemmer, D.E., and Marletta, M.A. (2009). A structural basis for N-NOX signaling inShewanellaoneidensisby trapping a histidine kinase inhibitory conformation. Proc. Natl. Acad. Sci. USA106: 19753-19760. 

Tian, C., Beeson, W.T., Iavarone, A.T., Sun, J., Marletta, M.A., Cate, J.H., and Glass, N.L. (2009).  Systems analysis of plant cell wall degradation by the model filamentous fungusNeurosporacrassa.  Proc. Natl. Acad. Sci. USA.106: 22157-22162.

 

部分名著与科研绩效:

http://scholar.google.com/scholar?hl=en&q=Michael+A+Marletta&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0

MAMarletta, PS Yoon, R Iyengar, CD Leaf, JS … - Biochemistry, 1988 - ACS Publications
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Laskey, R. A,, Gurdon, JB, & Trendelenburg, M. (1979)...LeBowitz, JH, & McMacken, R.
4IB#V8[4V.P;d4W-GFV0(1986) J. Biol. Chem. 261,...Lohka, MJ, & Masui, Y. (1983) J . Cell Biol. 98, 1222-1230.
@6{z KojA ]'D!k b0Maniatis, T., Fritsch, EF, & Sambrook, J. (1982) Molecular Cloning. A Laboratory Manual,...
`*O v2W&K cN0Cited by 1168-Related articles-All 5 versions

 

pnas.org[PDF]DJ Stuehr, MAMarletta- Proceedings of the National …, 1985 - National Acad Sciences分析测试百科网h'p"H3ebA4c
ABSTRACT Escherichia coli lipopolysaccharide (LPS)- induced nitrate biosynthesis was studied
V0JWtfD0in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of15
9x6G.`ar1I5W I o0,ugofLPSledtoatemporary5-to6-foldincrease in blood nitrate concentration in the C3H/He...分析测试百科网 xejDZ DA%T6p
Cited by 799-Related articles-All 8 versions

 

umich.edu[PDF]MAMarletta- Cell, 1994 - deepblue.lib.umich.edu分析测试百科网+}} U*[JtM
The rapid development of our understanding of the biologi- cal actions of nitric oxide (NO)分析测试百科网\'xSq5_Ml
has, to a large degree, been paralleled by our understanding of the enzyme responsi- ble for分析测试百科网6WT+f P+Wvg g'I2O
the synthesis of NO, nitric oxide synthase (NOS). The relatively fast pace of advance in...分析测试百科网n2r"n"vI]"J r
Cited by 653-Related articles-View as HTML-BL Direct-All 6 versions

 

pnas.org[PDF]… Iyengar, DJ Stuehr, MAMarletta- Proceedings of the …, 1987 - National Acad Sciences
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ABSTRACT The macrophage cell line RAW 264.7 when activated with Escherichia coli lipopolysaccharide分析测试百科网,Qp-H.n/`sv
and inter- feron-y synthesized nitrite (NO-) and nitrate (NO-). Medium change after the activation
R+oeb!~y0showed that L-arginine was the only amino acid essential for this synthesis. D-Arginine...分析测试百科网9Q"VF;MN8V:rS
Cited by 487-Related articles-All 10 versions

 

JW Denninger, MAMarletta- Biochimica et Biophysica Acta (BBA)- …, 1999 - Elsevier分析测试百科网r*cdk|1K){ m yEJ8][
Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of important
k"a,GaEX0physiological processes, including smooth muscle relaxation and neurotransmission. Soluble
L'\*}}c b:e0guanylate cyclase (sGC), a heterodimeric enzyme that converts guanosine triphosphate...分析测试百科网|8p@!? f/R P2|+rP|
Cited by 496-Related articles-All 5 versions

 

KA White, MAMarletta- Biochemistry, 1992 - ACS Publications分析测试百科网:x0Q2AN-NI
The formation of nitric oxide ('NO)' from L-arginine in mammalian cells is catalyzed by the enzyme
7Ma$nID#a.EU'S0'NO synthase (NOS; EC 1.14.23). This enzymatic activity has been associated with a number
'P/\Z^DwT&`Zi0of important physiological functions including maintenance of vascular tone, neuronal...
T(z$A![VH-Gu0Cited by 451-Related articles-All 3 versions

 

JR Stone, MAMarletta- Biochemistry, 1994 - ACS Publications
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Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and...Carbon Monoxide
Lu z;I8P0and Spectral Characterization of the Ferrous and Ferric States?...James R. Stone$ andMichael分析测试百科网 l6ux+c$s| S
A.Marletta'J.1 Department of Biological Chemistry, School of Medicine, and...
i'hbX8_4b b0Cited by 395-Related articles-BL Direct-All 3 versions

 

pnas.org[PDF]… Mulligan, JM Hevel, MAMarletta, … - Proceedings of the …, 1991 - National Acad Sciences
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...Tissue injury caused by deposition of immune complexes is L-arginine dependent分析测试百科网 t^+Q1a E
(NG-monomethyl-L-arginine/hydroxyl radical/superoxide/nitric oxide)MICHAELS. MULLIGAN*,
RgU [{0JOAN M. HEVELt,MICHAELA. MARLETTAtt, AND PETER A. WARD*§...
j$g2w FEM^ r$J q0]0Cited by 319-Related articles-All 13 versions

 

MAMarletta- Trends in Biochemical Sciences, 1989 - Elsevier分析测试百科网/?VC-m#r xV
The recent discovery that mammalian cells can synthesize nitric oxide coincided with the identification分析测试百科网I.^ G@t3P3rY'_!a
of this simple gas as a factor involved in cellular communication. Nitric oxide has now been shown分析测试百科网F5a!s%x Qdd
to be derived from l-arginine in macrophages, endothelial cells and possibly other cell...
T1D-@-of&F.Q0Cited by 287-Related articles-All 4 versions

 

aacrjournals.org[PDF]DJ Stuehr, MAMarletta- Cancer research, 1987 - AACR
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Synthesis of nitrite (NCV) and nitrate (NOD was studied in the macrophage cell lines RAW分析测试百科网[u"DU8T2N \!oY
264.7, WEHI-3, PU5-1.8, J774A.1, and P388D1 and compared to the synthesis by分析测试百科网9m-wTW^5Q&E
thioglycolate-elicited perito neal macrophages from ('31I/Ile and C3H/HeJ mice....
+hy7I c7P1\/e0Cited by 270-Related articles-All 3 versions
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