介绍生物基本实验技术、细胞生物学、微生物、植物学、遗传学等相关实验操作、仪器使用、试剂、注意事项等等。请大家多多指点,记得给我评论哦!

科学家 Michael A Marletta (生物化学)

上一篇 / 下一篇  2010-07-22 14:19:06 / 个人分类:基本实验技术

文章来源
  • 文章来源:转载

http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=marlettam

Michael Marletta

Aldo DeBenedictis Distinguished Professor of Chemistry and Professor of Biochemistry and Molecular Biology

Lab Homepage:http://www.cchem.berkeley.edu/mmargrp/

EnvFull Directory Information

Research Interests

Research in this laboratory is focused on structure/function relationships in proteins with a particular emphasis on the catalytic and biological properties of enzymes and signaling proteins. Current emphasis is on nitric oxide signaling (including studies on nitric oxide synthase, guanylate cyclase and S-nitrosation mechanisms), oxygen sensing, pathogen responses to nitric oxide, and enzymology of biofuel utilization.

 

 

Michael A Marletta
^'KuJ/tHv0Department of Chemistry, University of California, Berkeley, USA

分析测试百科网,H&["v){0@4@
Head of Section:Chemical Biology > Bioinorganic Chemistry [ since 7 February 2005 ]
[Homepage]
Home page
K u X4J%e|xv y0

http://mcb.berkeley.edu/faculty/BMB/marlettam.html

最新研究成果:

Carlson, H.K., Plate, L., Price, M.S., Allen, J.J., Shokat, K.M., and Marletta, M.A. (2010).  Use of a semisynthetic epitope to probe histidine Kinase activity and regulation. Anal. Biochem.397: 139-143.

Weinert, E.E., Plate, L., Whited, C.A., Olea, C. Jr, and Marletta, M.A. (2010). Determinants of ligand affinity and heme reactivity in H-NOX domains. Angew. Chem. Int. Ed. Engl.49: 720-723. 

Olea, C. Jr, Herzik, M.A. Jr, Kuriyan, J., and Marletta, M.A. (2010). Structural insights into the molecular mechanism of H-NOX activation. Protein Science19: 881-887. 

Woodward, J.J., Nejatyjahromy, Y., Britt, R.D., and Marletta, M.A.  (2010). Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase.J. Amer. Chem. Soc.132: 5105-5113.

Wang, Y., Dufour, Y.S., Carlson, H.K.,Donohue, T.J., Marletta, M.A., and Ruby, E.G. (2010). H-NOX-mediated NO sensing modulates symbiotic colonization byVibrio fischeriProc. Natl. Acad. Sci. USA107: 8375-8380.

Derbyshire, E.R., Fernhoff, N.B., Deng, S. and Marletta, M. A. (2009). Nucleotide regulation of soluble guanylate cyclase substrate specificity. Biochemistry48: 7519-7524.

Agapie, T., Suseno, S., Woodward, J.J., Stoll, S., Britt, R.D., and Marletta, M.A. (2009). NO Formation by a Protein fromSorangium cellulosum: A Catalytically Self-Sufficient Bacterial Nitric Oxide Synthase. Proc. Natl. Acad. Sci. USA106: 16221-16226. 

Fernhoff, N.B., Derbyshire, E.R. and Marletta, M.A. (2009). A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc. Natl. Acad. Sci. USA106: 21602-22607.

Erbil, W.K., Price, M.S., Wemmer, D.E., and Marletta, M.A. (2009). A structural basis for N-NOX signaling inShewanellaoneidensisby trapping a histidine kinase inhibitory conformation. Proc. Natl. Acad. Sci. USA106: 19753-19760. 

Tian, C., Beeson, W.T., Iavarone, A.T., Sun, J., Marletta, M.A., Cate, J.H., and Glass, N.L. (2009).  Systems analysis of plant cell wall degradation by the model filamentous fungusNeurosporacrassa.  Proc. Natl. Acad. Sci. USA.106: 22157-22162.

 

部分名著与科研绩效:

http://scholar.google.com/scholar?hl=en&q=Michael+A+Marletta&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0

MAMarletta, PS Yoon, R Iyengar, CD Leaf, JS … - Biochemistry, 1988 - ACS Publications分析测试百科网w i5o/L1QKT1QrNsu
Laskey, R. A,, Gurdon, JB, & Trendelenburg, M. (1979)...LeBowitz, JH, & McMacken, R.分析测试百科网4?-`m.A&b/]
(1986) J. Biol. Chem. 261,...Lohka, MJ, & Masui, Y. (1983) J . Cell Biol. 98, 1222-1230.
'I3{'Z[B@X6jtk0Maniatis, T., Fritsch, EF, & Sambrook, J. (1982) Molecular Cloning. A Laboratory Manual,...分析测试百科网$F xn3J q3G|N h@
Cited by 1168-Related articles-All 5 versions

 

pnas.org[PDF]DJ Stuehr, MAMarletta- Proceedings of the National …, 1985 - National Acad Sciences分析测试百科网+G#B5N.]u%l+W
ABSTRACT Escherichia coli lipopolysaccharide (LPS)- induced nitrate biosynthesis was studied
D \.Q/u1Ct0X}3~0in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of15
MP`qJA"G;U0,ugofLPSledtoatemporary5-to6-foldincrease in blood nitrate concentration in the C3H/He...
1m*{%Ur9MI8g5k0Cited by 799-Related articles-All 8 versions

 

umich.edu[PDF]MAMarletta- Cell, 1994 - deepblue.lib.umich.edu
$w4y4JI E~B }~0
The rapid development of our understanding of the biologi- cal actions of nitric oxide (NO)
9F \}a+F{,X0has, to a large degree, been paralleled by our understanding of the enzyme responsi- ble for
e @,ie1l4W0the synthesis of NO, nitric oxide synthase (NOS). The relatively fast pace of advance in...
OEGC |n{@^0Cited by 653-Related articles-View as HTML-BL Direct-All 6 versions

 

pnas.org[PDF]… Iyengar, DJ Stuehr, MAMarletta- Proceedings of the …, 1987 - National Acad Sciences
[[RI6i.[k5T(|0
ABSTRACT The macrophage cell line RAW 264.7 when activated with Escherichia coli lipopolysaccharide分析测试百科网 z\C1{ClM/fd
and inter- feron-y synthesized nitrite (NO-) and nitrate (NO-). Medium change after the activation
M/GHEN^p0showed that L-arginine was the only amino acid essential for this synthesis. D-Arginine...分析测试百科网H3Ktyh#u{&s
Cited by 487-Related articles-All 10 versions

 

JW Denninger, MAMarletta- Biochimica et Biophysica Acta (BBA)- …, 1999 - Elsevier
O.Wo8dE0
Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of important分析测试百科网8fi1ip)V]T
physiological processes, including smooth muscle relaxation and neurotransmission. Soluble分析测试百科网\0Bl!I w:L
guanylate cyclase (sGC), a heterodimeric enzyme that converts guanosine triphosphate...
.Y"iI:YmSV e8]0Cited by 496-Related articles-All 5 versions

 

KA White, MAMarletta- Biochemistry, 1992 - ACS Publications
&gG0`"A8o0\0
The formation of nitric oxide ('NO)' from L-arginine in mammalian cells is catalyzed by the enzyme
|-u!oRNZ|0'NO synthase (NOS; EC 1.14.23). This enzymatic activity has been associated with a number分析测试百科网G,O1o:h7T o
of important physiological functions including maintenance of vascular tone, neuronal...
x~Rs3| {KRn0Cited by 451-Related articles-All 3 versions

 

JR Stone, MAMarletta- Biochemistry, 1994 - ACS Publications
jRs%}"Ra3NC0
Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and...Carbon Monoxide
9J(H%zf-b X-B!|,d'j0and Spectral Characterization of the Ferrous and Ferric States?...James R. Stone$ andMichael
y*j#I`$d5s)Q"j0A.Marletta'J.1 Department of Biological Chemistry, School of Medicine, and...分析测试百科网1EL,_#[V[
Cited by 395-Related articles-BL Direct-All 3 versions

 

pnas.org[PDF]… Mulligan, JM Hevel, MAMarletta, … - Proceedings of the …, 1991 - National Acad Sciences
g/D[K/v~0d8~dU0
...Tissue injury caused by deposition of immune complexes is L-arginine dependent分析测试百科网WO)B6G;jH r
(NG-monomethyl-L-arginine/hydroxyl radical/superoxide/nitric oxide)MICHAELS. MULLIGAN*,
FD;K ZM2yZ J0JOAN M. HEVELt,MICHAELA. MARLETTAtt, AND PETER A. WARD*§...
.g&fX&n:{_5[I0Cited by 319-Related articles-All 13 versions

 

MAMarletta- Trends in Biochemical Sciences, 1989 - Elsevier
1G:o:fV A,P0
The recent discovery that mammalian cells can synthesize nitric oxide coincided with the identification
xV$M&cY4l*w2s0of this simple gas as a factor involved in cellular communication. Nitric oxide has now been shown分析测试百科网0bI9Zs s4J-j+m$Q |[
to be derived from l-arginine in macrophages, endothelial cells and possibly other cell...
;Nr/Y&Kh0Cited by 287-Related articles-All 4 versions

 

aacrjournals.org[PDF]DJ Stuehr, MAMarletta- Cancer research, 1987 - AACR分析测试百科网9?;WXHz1G'W0q W%[Y
Synthesis of nitrite (NCV) and nitrate (NOD was studied in the macrophage cell lines RAW分析测试百科网}o.a'[m-zB.K6c1\
264.7, WEHI-3, PU5-1.8, J774A.1, and P388D1 and compared to the synthesis by
n m5Soo)D0thioglycolate-elicited perito neal macrophages from ('31I/Ile and C3H/HeJ mice....分析测试百科网!L:Ll`E!e
Cited by 270-Related articles-All 3 versions
]9[\|R)Y3a|k7y0
\A2?;T0g0
?s/u9b]0

分析化学  仪器分析  红外光谱


G_d*["R@ DLq0

TAG: 生物化学

 

评分:0

我来说两句

显示全部

:loveliness: :handshake :victory: :funk: :time: :kiss: :call: :hug: :lol :'( :Q :L ;P :$ :P :o :@ :D :( :)

Open Toolbar