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科学家 Michael A Marletta (生物化学)

上一篇 / 下一篇  2010-07-22 14:19:06 / 个人分类:基本实验技术

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http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=marlettam

Michael Marletta

Aldo DeBenedictis Distinguished Professor of Chemistry and Professor of Biochemistry and Molecular Biology

Lab Homepage:http://www.cchem.berkeley.edu/mmargrp/

EnvFull Directory Information

Research Interests

Research in this laboratory is focused on structure/function relationships in proteins with a particular emphasis on the catalytic and biological properties of enzymes and signaling proteins. Current emphasis is on nitric oxide signaling (including studies on nitric oxide synthase, guanylate cyclase and S-nitrosation mechanisms), oxygen sensing, pathogen responses to nitric oxide, and enzymology of biofuel utilization.

 

 

Michael A Marletta分析测试百科网4Zs%kKBj} N
Department of Chemistry, University of California, Berkeley, USA

分析测试百科网3K {t+T3y
Head of Section:Chemical Biology > Bioinorganic Chemistry [ since 7 February 2005 ]
[Homepage]
Home page
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http://mcb.berkeley.edu/faculty/BMB/marlettam.html

最新研究成果:

Carlson, H.K., Plate, L., Price, M.S., Allen, J.J., Shokat, K.M., and Marletta, M.A. (2010).  Use of a semisynthetic epitope to probe histidine Kinase activity and regulation. Anal. Biochem.397: 139-143.

Weinert, E.E., Plate, L., Whited, C.A., Olea, C. Jr, and Marletta, M.A. (2010). Determinants of ligand affinity and heme reactivity in H-NOX domains. Angew. Chem. Int. Ed. Engl.49: 720-723. 

Olea, C. Jr, Herzik, M.A. Jr, Kuriyan, J., and Marletta, M.A. (2010). Structural insights into the molecular mechanism of H-NOX activation. Protein Science19: 881-887. 

Woodward, J.J., Nejatyjahromy, Y., Britt, R.D., and Marletta, M.A.  (2010). Pterin-Centered Radical as a Mechanistic Probe of the Second Step of Nitric Oxide Synthase.J. Amer. Chem. Soc.132: 5105-5113.

Wang, Y., Dufour, Y.S., Carlson, H.K.,Donohue, T.J., Marletta, M.A., and Ruby, E.G. (2010). H-NOX-mediated NO sensing modulates symbiotic colonization byVibrio fischeriProc. Natl. Acad. Sci. USA107: 8375-8380.

Derbyshire, E.R., Fernhoff, N.B., Deng, S. and Marletta, M. A. (2009). Nucleotide regulation of soluble guanylate cyclase substrate specificity. Biochemistry48: 7519-7524.

Agapie, T., Suseno, S., Woodward, J.J., Stoll, S., Britt, R.D., and Marletta, M.A. (2009). NO Formation by a Protein fromSorangium cellulosum: A Catalytically Self-Sufficient Bacterial Nitric Oxide Synthase. Proc. Natl. Acad. Sci. USA106: 16221-16226. 

Fernhoff, N.B., Derbyshire, E.R. and Marletta, M.A. (2009). A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc. Natl. Acad. Sci. USA106: 21602-22607.

Erbil, W.K., Price, M.S., Wemmer, D.E., and Marletta, M.A. (2009). A structural basis for N-NOX signaling inShewanellaoneidensisby trapping a histidine kinase inhibitory conformation. Proc. Natl. Acad. Sci. USA106: 19753-19760. 

Tian, C., Beeson, W.T., Iavarone, A.T., Sun, J., Marletta, M.A., Cate, J.H., and Glass, N.L. (2009).  Systems analysis of plant cell wall degradation by the model filamentous fungusNeurosporacrassa.  Proc. Natl. Acad. Sci. USA.106: 22157-22162.

 

部分名著与科研绩效:

http://scholar.google.com/scholar?hl=en&q=Michael+A+Marletta&btnG=Search&as_sdt=2000&as_ylo=&as_vis=0

MAMarletta, PS Yoon, R Iyengar, CD Leaf, JS … - Biochemistry, 1988 - ACS Publications
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Laskey, R. A,, Gurdon, JB, & Trendelenburg, M. (1979)...LeBowitz, JH, & McMacken, R.分析测试百科网^.z3]X9q/^#td
(1986) J. Biol. Chem. 261,...Lohka, MJ, & Masui, Y. (1983) J . Cell Biol. 98, 1222-1230.
J0d/oO^9Z3\ d'Jm0Maniatis, T., Fritsch, EF, & Sambrook, J. (1982) Molecular Cloning. A Laboratory Manual,...
{A],z1| d0Cited by 1168-Related articles-All 5 versions

 

pnas.org[PDF]DJ Stuehr, MAMarletta- Proceedings of the National …, 1985 - National Acad Sciences
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ABSTRACT Escherichia coli lipopolysaccharide (LPS)- induced nitrate biosynthesis was studied分析测试百科网kEM9M)p;m
in LPS-sensitive C3H/He and LPS-resistant C3H/HeJ mice. Intraperitoneal injection of15分析测试百科网8A@*P0Rw'cy0O d]
,ugofLPSledtoatemporary5-to6-foldincrease in blood nitrate concentration in the C3H/He...
7J7R4K~K0Cited by 799-Related articles-All 8 versions

 

umich.edu[PDF]MAMarletta- Cell, 1994 - deepblue.lib.umich.edu分析测试百科网(m Ds9i c!a
The rapid development of our understanding of the biologi- cal actions of nitric oxide (NO)分析测试百科网j8P-Jw8R
has, to a large degree, been paralleled by our understanding of the enzyme responsi- ble for
_0sd eghEB0the synthesis of NO, nitric oxide synthase (NOS). The relatively fast pace of advance in...分析测试百科网8i$o$IRRe
Cited by 653-Related articles-View as HTML-BL Direct-All 6 versions

 

pnas.org[PDF]… Iyengar, DJ Stuehr, MAMarletta- Proceedings of the …, 1987 - National Acad Sciences
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ABSTRACT The macrophage cell line RAW 264.7 when activated with Escherichia coli lipopolysaccharide
URfQ%Z0and inter- feron-y synthesized nitrite (NO-) and nitrate (NO-). Medium change after the activation
(d%g Z T V:Y;e0showed that L-arginine was the only amino acid essential for this synthesis. D-Arginine...
)U%y9l*u/|0Cited by 487-Related articles-All 10 versions

 

JW Denninger, MAMarletta- Biochimica et Biophysica Acta (BBA)- …, 1999 - Elsevier
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Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of important
^j/P+@&az0physiological processes, including smooth muscle relaxation and neurotransmission. Soluble
*u7EWB"T4L,F.T5A0guanylate cyclase (sGC), a heterodimeric enzyme that converts guanosine triphosphate...
&udc,s3{${0Cited by 496-Related articles-All 5 versions

 

KA White, MAMarletta- Biochemistry, 1992 - ACS Publications
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The formation of nitric oxide ('NO)' from L-arginine in mammalian cells is catalyzed by the enzyme分析测试百科网O7n-F UP8c.h
'NO synthase (NOS; EC 1.14.23). This enzymatic activity has been associated with a number分析测试百科网-O!ZF#FL^,Dv
of important physiological functions including maintenance of vascular tone, neuronal...分析测试百科网2zR9Ti.X5Pks_
Cited by 451-Related articles-All 3 versions

 

JR Stone, MAMarletta- Biochemistry, 1994 - ACS Publications分析测试百科网!dMk/ii]/d;]-z \
Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and...Carbon Monoxide
j*r:hsd2ry0and Spectral Characterization of the Ferrous and Ferric States?...James R. Stone$ andMichael
n^G?MV#`#pg0A.Marletta'J.1 Department of Biological Chemistry, School of Medicine, and...分析测试百科网@0CA1Aa o
Cited by 395-Related articles-BL Direct-All 3 versions

 

pnas.org[PDF]… Mulligan, JM Hevel, MAMarletta, … - Proceedings of the …, 1991 - National Acad Sciences分析测试百科网7oH#E.T$r6z)e8x` r
...Tissue injury caused by deposition of immune complexes is L-arginine dependent分析测试百科网 A)|&pT,wX~
(NG-monomethyl-L-arginine/hydroxyl radical/superoxide/nitric oxide)MICHAELS. MULLIGAN*,分析测试百科网,F'fW{2KT%wtAz aK"b
JOAN M. HEVELt,MICHAELA. MARLETTAtt, AND PETER A. WARD*§...分析测试百科网1@(p IK6e
Cited by 319-Related articles-All 13 versions

 

MAMarletta- Trends in Biochemical Sciences, 1989 - Elsevier
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The recent discovery that mammalian cells can synthesize nitric oxide coincided with the identification
n&tQ$TE0of this simple gas as a factor involved in cellular communication. Nitric oxide has now been shown
!`2H;u2wS"V[y:Z/N0to be derived from l-arginine in macrophages, endothelial cells and possibly other cell...分析测试百科网;D7Wj{3T!V,?'X O
Cited by 287-Related articles-All 4 versions

 

aacrjournals.org[PDF]DJ Stuehr, MAMarletta- Cancer research, 1987 - AACR
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Synthesis of nitrite (NCV) and nitrate (NOD was studied in the macrophage cell lines RAW
f&ob3_ qDG0264.7, WEHI-3, PU5-1.8, J774A.1, and P388D1 and compared to the synthesis by
Aa%V;Oz5xF {?p0thioglycolate-elicited perito neal macrophages from ('31I/Ile and C3H/HeJ mice....
HE9cBA5?0Cited by 270-Related articles-All 3 versions分析测试百科网p d*l,LL,kH|j#y8R

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