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人类家族基因突变与疾病发生的知识发现

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知识发现平台 http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/edit_b.cgi

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A-Literature

C-Literature

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A-query: genome-wide mutation rates
C-query: human families

The B-list contains title words and phrases (terms) that appeared in both the A and the C literature. 11 articles appeared in both literatures and were not included in the process of computing the B-list but can be viewed here. The results of this search are saved under id # 2504 and can be accessed from the start page after you leave this session. There are 8 terms on the current B-list (5 are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/view_b_txt.cgi?ID=2504

job id # 2504 started Wed Jun 15 21:06:35 2011
Max_citations: 50000
Stoplist: /var/www/html/arrowsmith_uic/data/stopwords_pubmed
Ngram_max: 3
2504 Search ARROWSMITH A
A_query_raw: endocytosis and tumorigenicityWed Jun 15 21:06:49 2011

A query = endocytosis and tumorigenicity started Wed Jun 15 21:06:49 2011
A query resulted in 15 titles
2504 Search ARROWSMITH C
C_query_raw: tyrosine kinase Wed Jun 15 21:07:17 2011

C: tyrosine kinase 141772

A: pubmed_query_A 15

AC: ( endocytosis and tumorigenicity ) AND ( tyrosine kinase ) 5

C query = tyrosine kinase started Wed Jun 15 21:07:18 2011
C query resulted in 50000 titles
2504 Search ARROWSMITH A
A_query_raw: genome-wide mutation rates Wed Jun 15 21:08:41 2011

A query = genome-wide mutation rates started Wed Jun 15 21:08:42 2011
A query resulted in 183 titles
2504 Search ARROWSMITH C
C_query_raw: human families Wed Jun 15 21:09:12 2011

C: human families 610349

A: pubmed_query_A 183

AC: ( genome-wide mutation rates ) AND ( human families ) 11

C query = human families started Wed Jun 15 21:09:13 2011
C query resulted in 50000 titles
A AND C query resulted in 11 titles
1178 B-terms ready on Wed Jun 15 21:11:14 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
104 B-terms left after filter executed Wed Jun 15 21:13:15 2011

Sem_filter:
Disorders
8 B-terms left after filter executed Wed Jun 15 21:17:02 2011

B-list on Wed Jun 15 21:29:26 2011

人类家族基因突变与疾病发生的关系，具有密切相关性的隐含知识概念有：
1 inflammatory bowel disease 炎性肠疾病
2 genomic 基因组
3 wilm tumor 维尔姆瘤
4 disease gene 疾病基因
5 breast cancer 乳腺癌

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

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A-Literature

C-Literature

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AB literature

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BC literature

genome-wide mutation rates

breast cancer

human families

1: DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status. 2010
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2: Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in a breast cancer cell line. 2009
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1: Global DNA methylation levels in girls with and without a family history of breast cancer. 2011
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2: Breast cancer genomics based on biobanks. 2011
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3: Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in human breast cancers. 2011
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4: Side population in MDA-MB-231 human breast cancer cells exhibits cancer stem cell-like properties without higher bone-metastatic potential. 2011
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5: Physical activity and breast cancer prevention. 2011
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