人类家族基因突变与疾病发生的知识发现

上一篇 / 下一篇  2011-06-17 14:49:39 / 个人分类:科学探索

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StartA-LiteratureC-LiteratureB-listFilterLiterature
A-query: genome-wide mutation rates
C-query: human families
The B-list contains title words and phrases (terms) that appeared in both the A and the C literature.11articles appeared in both literatures and were not included in the process of computing the B-list but can be viewedhere. The results of this search are saved under id #2504and can be accessed from the start page after you leave this session. There are8terms on the current B-list (5are predicted to be relevant), which is shown ranked according to predicted relevance. The list can be further trimmed down using the filters listed in the left margin.

To assess whether there appears to be a biologically significant relationship between the AB and BC literatures for specific B-terms, please select one or more B-terms and then click the button to view the corresponding AB and BC literatures. Use Ctrl to select multiple B-terms.

 
 
job id # 2504 started Wed Jun 15 21:06:35 2011
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2504 Search ARROWSMITH A
A_query_raw: endocytosis and tumorigenicityWed Jun 15 21:06:49 2011

A query = endocytosis and tumorigenicity started Wed Jun 15 21:06:49 2011
A query resulted in 15 titles
2504 Search ARROWSMITH C
C_query_raw: tyrosine kinase Wed Jun 15 21:07:17 2011

C: tyrosine kinase 141772

A: pubmed_query_A 15

AC: ( endocytosis and tumorigenicity ) AND ( tyrosine kinase ) 5

C query = tyrosine kinase started Wed Jun 15 21:07:18 2011
C query resulted in 50000 titles
2504 Search ARROWSMITH A
A_query_raw: genome-wide mutation rates Wed Jun 15 21:08:41 2011

A query = genome-wide mutation rates started Wed Jun 15 21:08:42 2011
A query resulted in 183 titles
2504 Search ARROWSMITH C
C_query_raw: human families Wed Jun 15 21:09:12 2011

C: human families 610349

A: pubmed_query_A 183

AC: ( genome-wide mutation rates ) AND ( human families ) 11

C query = human families started Wed Jun 15 21:09:13 2011
C query resulted in 50000 titles
A AND C query resulted in 11 titles
1178 B-terms ready on Wed Jun 15 21:11:14 2011

Sem_filter:
Genes & Molecular Sequences, and Gene & Protein Names
104 B-terms left after filter executed Wed Jun 15 21:13:15 2011

Sem_filter:
Disorders
8 B-terms left after filter executed Wed Jun 15 21:17:02 2011

B-list on Wed Jun 15 21:29:26 2011

人类家族基因突变与疾病发生的关系,具有密切相关性的隐含知识概念有:
1 inflammatory bowel disease  炎性肠疾病
2 genomic 基因组
3 wilm tumor  维尔姆瘤
4 disease gene  疾病基因
5 breast cancer  乳腺癌

http://arrowsmith.psych.uic.edu/cgi-bin/arrowsmith_uic/show_sentences.cgi

StartA-LiteratureC-LiteratureB-listFilterLiterature
AB literatureB-termBC literature
genome-wide mutation ratesbreast cancerhuman families
1:DNA Methylome of FamilialBreast CancerIdentifies Distinct Profiles Defined by Mutation Status. 2010
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2:Data integration from two microarray platforms identifies bi-allelic genetic inactivation of RIC8A in abreast cancercell line. 2009
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1:Global DNA methylation levels in girls with and without a family history ofbreast cancer. 2011
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2:Breast cancergenomics based on biobanks. 2011
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3:Overexpression of human ortholog of mammalian enabled (hMena) is associated with the expression of mutant p53 protein in humanbreast cancers. 2011
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4:Side population in MDA-MB-231 humanbreast cancercells exhibits cancer stem cell-like properties without higher bone-metastatic potential. 2011
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5:Physical activity andbreast cancerprevention. 2011
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TAG: 人类 疾病

 

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