The potential cardioprotective effects of hydrogen in
Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, Zaho L, Jiang
H, Cai J.
Department of Radiation Medicine, Faculty of Naval Medicine,
Second Military Medical University.
Most ionizing radiation-induced damage is caused by hydroxyl
radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been
demonstrated previously. Irradiation of the heart can cause chronic cardiac
disease. This study was designed to test the hypothesis that hydrogen-rich water
(pure water saturated with molecular hydrogen), which is easy to use, induces
cardioprotection against ionizing irradiation injury in mice. In this paper, we
demonstrate that hydrogen can protect myocardium degeneration from
radiation-induced injury, decrease myocardium malondialdehyde (MDA),
8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous
antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect
against radiation induced injury.