氢气对放射性心脏损伤的治疗作用

　　氢气的选择性抗氧化的发现，引起了氢气生物学研究的热潮，氢气治疗各类器官移植、缺血再灌注损伤、炎症研究是氢气生物学领域的主要研究内容。放射损伤与自由基的关系是自由基生物学最早涉及的领域，抗自由基在放射损伤防护仍是目前的主流方法，国际上采用抗自由基对抗辐射损伤仍是临床上的主要手段。不过目前抗辐射损伤药物由于存在非常明显的毒性作用，限制了这些药物的使用。氢气由于没有任何毒性作用，如果能用于抗辐射损伤，将是这个领域的重要发现，会对临床上放射治疗和放射诊断过程中引起的损伤的有效预防带来重要贡献。目前，第二军医大学放射医学研究已经先后发表了4篇使用氢气溶液治疗放射损伤的论文，证明氢气能治疗放射性淋巴细胞和肠细胞损伤，在国际上已经逐渐成为氢气生物学方向的一个特色。

　　本研究主要是为了证明氢气溶液对放射引起的心脏损伤保护效应的观察，研究发现氢气可显著提高放射后动物生存率，并对放射引起的心脏损伤具有明显的治疗作用，同时能降低心脏氧化损伤，提高抗氧化酶水平。研究结果提示氢气在放射性心脏损伤中具有潜在的临床应用前景。

　　J Radiat Res (Tokyo). 2010;51(6):741-7.

　　The potential cardioprotective effects of hydrogen in irradiated mice.

　　Qian L, Cao F, Cui J, Wang Y, Huang Y, Chuai Y, Zaho L, Jiang H, Cai J.

　　Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University.

　　Abstract

　　Most ionizing radiation-induced damage is caused by hydroxyl radicals, and the selective reduction of hydroxyl by hydrogen in vitro has been demonstrated previously. Irradiation of the heart can cause chronic cardiac disease. This study was designed to test the hypothesis that hydrogen-rich water (pure water saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ionizing irradiation injury in mice. In this paper, we demonstrate that hydrogen can protect myocardium degeneration from radiation-induced injury, decrease myocardium malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG) levels, and increase myocardium endogenous antioxidants in vivo. We suggest that hydrogen has a cardioprotective effect against radiation induced injury.