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通过产氢发挥作用的新型药物

上一篇 / 下一篇 2010-07-29 10:38:52/ 个人分类：新药研发

显然这个文章的研究方法并没有太多新意，但是作者提供了一种新的给氢气的方法，是本文的亮点。如果这种方法能得到更多验证，将代表一种新的研究方向。我已经写信要求作者提供一些样品，可能的话我们将采用成熟模型验证这种方法，并根据其思路开发类似的化合物。

07年氢气生物学效应发现以来，人们对氢气的生物学效应在多中动物模型中证明了显著的效果，分别采用呼吸、饮含氢气的水和注射含氢气生理盐水等给氢气的手段，当然也有通过诱导身体自身产生氢气的方法，例如用药物如派拜糖平（阿卡波糖）、食物如生姜（姜黄素）海带（甘露醇）牛奶、电针，当然这些方法有的没有全部用氢气的效应来解释，但都是比较理想的治疗手段。显然有另外一种手段很容易被人们注意，就是给机体提供能释放氢气的药物，类似于硝酸甘油释放一氧化氮、COMR释放一氧化碳、硫氢化钠释放硫化氢，这类物质将有成为潜在药物的可能，现在日本有一个公司提供了一种能产生氢气的物质Coral Calcium Hydride，字面意思是珊瑚氢化钙，或者氢化珊瑚钙，估计是类似生物可降解材料，如果是这样的话，本身也没有太多技术含量，原理也不会太复杂，做材料的人比较容易能实现这个技术。有个疑问是，生物可降解材料用的更多是金属镁，现在他们使用钙，不知道什么道理？请作化学的老师帮助解释。全文

Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride

Abstract

This study explored the effect of coral calcium hydride (CCH) on rat intrahippocampal antioxidant ability by measuring the PCAM nitroxide radical decay ratio when CCH was (a) co-perfused into the hippocampus and (b) fed orally to the rats for 4 weeks under a freely moving state. Estimation of the in vivo antioxidant effect was obtained by administration of the blood–brain barrier-permeable PCAM nitroxide radical and the measured PCAM radical decay ratio then correlated to the amount of antioxidant in the brain using electron spin resonance (ESR) spectroscopy combined with microdialysis. The half-life periods of PCAM in rats treated with CCH in both the co-perfusion and orally fed groups were significantly shorter compared to the control group. These results clarify the mechanism that CCH may exert antioxidant activity by significantly enhancing the basal endogenous antioxidant ability in the hippocampus through a synergistic effect with α-tocopherol and ascorbic acid.

Keywords Hydrogen gas - Antioxidant effect - Hippocampus - Rat - Microdialysis

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References

1 Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S (2007) Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med 13:688–694

Cai J, Kang Z, Liu WW, Luo X, Qiang S, Zhang JH, Ohta S, Sun X, Xu W, Tao H, Li R (2008) Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model. Neurosci Lett 441:167–172

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