Science :罗敏敏等发现一肠道激素受体与多动症有关

上一篇 / 下一篇  2011-08-26 21:47:37

文章来源
  • 文章来源:转载

中国研究人员8月11日在美国《科学》杂志上报告说,他们通过小鼠实验发现,一种肠道激素受体在脑中也发挥作用,缺乏这种激素受体将导致多动症。

多动症,也称注意力缺陷多动障碍,主要特征包括注意力不集中、多动和行为冲动等。

北京生命科学研究所罗敏敏研究员等人在论文中说,鸟苷酸环化酶-C是一种肠道激素受体,因基因改变而在脑内缺失鸟苷酸环化酶-C的小鼠注意力受到影响,表现出类似人类多动症的行为异常。

研究人员分析认为,鸟苷酸环化酶-C缺失导致行为异常的原因在于,它能调节脑内分泌物多巴胺的水平。而多巴胺神经元功能障碍被认为与数种人类神经精神性疾病有关,包括多动症和精神分裂症。

罗敏敏在接受新华社记者采访时说,这项研究成果可帮助发现多动症等神经精神性疾病的根源,找到“可能的治疗标靶”。(生物谷Bioon.com)

Role for the Membrane Receptor Guanylyl Cyclase-C in Attention Deficiency and Hyperactive Behavior

Gong, Rong; Ding, Cheng; Hu, Ji; Lu, Yao; Liu, Fei; Mann, Elizabeth; Xu, Fuqiang; Cohen, Mitchell B.; Luo, Minmin

Midbrain dopamine neurons regulate many important behavioral processes, and their dysfunctions are associated with several human neuropsychiatric disorders such as Attention Deficit Hyperactivity Disorder (ADHD) and schizophrenia. Here, we report that these neurons in mice selectively express guanylyl cyclase-C (GC-C), a membrane receptor previously thought to be expressed mainly in the intestine. GC-C activation potentiates the excitatory responses mediated by glutamate and acetylcholine receptors via the activity of cGMP-dependent protein kinase (PKG). GC-C knockout mice exhibit hyperactivity and attention deficits. Moreover, their behavioralphenotypes are reversed by ADHD therapeutics and a PKG activator. These results indicate important behavioral and physiological functions for the GC-C/PKG signaling pathway within the brain and suggest new therapeutic targets for neuropsychiatric disorders related to the malfunctions of midbrain dopamine neurons.


TAG:

 

评分:0

我来说两句

显示全部

:loveliness: :handshake :victory: :funk: :time: :kiss: :call: :hug: :lol :'( :Q :L ;P :$ :P :o :@ :D :( :)

日历

« 2016-12-03  
    123
45678910
11121314151617
18192021222324
25262728293031

数据统计

  • 访问量: 5385
  • 日志数: 126
  • 建立时间: 2011-08-24
  • 更新时间: 2011-09-11

RSS订阅

Open Toolbar