J. Proteome Res.：昆明动物所在抗菌肽研究方面取得重要进展

2011-4-6 11:28:58 来源：昆明动物研究所 作者：昆明动物研究所  【大 中  小】

药厂的竞争

合并与并购？

大鱼吃小鱼还是合并？医药巨头面临巨大的选择

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大量的抗菌肽已经从两栖动物的皮肤中发现，但从动物脑中很少报道。中国科学院昆明动物研究所赖仞研究员领导的课题组采用蛋白质组学结合基因组学的手段，从两种两栖动物（大蹼铃蟾和微蹼铃蟾）脑中识别了59种新抗菌肽分子，该研究表明两栖动物脑是重要的抗菌肽分子资源库。

该研究结果发表在国际知名期刊J Proteome Res. 2011;10:1806-15上，同时美国化学学会新闻周刊以“蟾蜍脑是发掘强力抗微生物武器的宝库”（Toad brains are a treasure trove of powerful germ-fighters）为题对该成果作了专门评述。

该研究成果得到了国家自然科学基金委员会和科技部的经费支持。推荐原文出处：

J. Proteome Res., 2011, 10 (4), pp 1806–1815   DOI: 10.1021/pr101285n

There are Abundant Antimicrobial Peptides in Brains of Two Kinds of Bombina Toads

Rui Liu?, Huan Liu§, Yufang Ma§, Jing Wu§, Hailong Yang§, Huahu Ye, and Ren Lai*?§

It is well-known that there is a large amount of antimicrobial peptides in amphibian skins but few antimicrobial peptides are found in amphibian brains. Twenty-two and four antimicrobial peptides were purified and characterized from the brain homogenate of Bombina maxima and B. microdeladigitora, respectively. One hundred fifty-eight cDNA clones encoding 79 antimicrobial peptides were isolated from brain cDNA libraries of B. maxima and B. microdeladigitora. These antimicrobial peptides belong to two peptide groups (maximin and maximin-H). Twenty of them are identical to previously reported antimicrobial peptides (maximin 1?8, 10, 11, maximin H1, 3?5, 7, 9, 10, 12, 15, 16) from B. maxima skin secretions. Fifty-nine of them are novel antimicrobial peptides. Some of these antimicrobial peptides showed strong antimicrobial activities against tested microorganism strains including Gram-positive and -negative bacteria and fungi. The current diversity in peptide coding cDNA sequences is, to our knowledge, the most extreme yet described for any animal brains. The extreme diversity may give rise to interest to prospect the actual functions of antimicrobial peptides in amphibian brains.

Keywords: antimicrobial peptides; brain; amphibian