来自中科院上海生命科学研究院生化与细胞所，广州生物医药与健康研究院等处的研究人员发表了题为“Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells”的文章，发现Rapamycin等抗衰老药物可以提高小鼠细胞重编程的效率，这说明生物体寿命的调节和细胞重编程过程的调控之间可能有着功能上的紧密联系，这一研究成果公布在国际著名期刊《衰老细胞》（Aging Cell）上，这一研究课题获得国家科技部973项目、国家自然科学基金委以及中国科学院干细胞先导专项的经费资助。
Keywords:longevity;drosophila;rapamycin;induced pluripotent stem cellsSummaryReprogramming of somatic cells to a pluripotent state was first accomplished using retroviral vectors for transient expression of pluripotency‐associated transcription factors. This seminal work was followed by numerous studies reporting alternative (noninsertional) reprogramming methods and various conditions to improve the efficiency of reprogramming. These studies have contributed little to an understanding of global mechanisms underlying reprogramming efficiency. Here we report that inhibition of the mammalian target of rapamycin (mTOR) pathway by rapamycin or PP242 enhances the efficiency of reprogramming to induced pluripotent stem cells (iPSCs). Inhibition of the insulin/IGF‐1 signaling pathway, which like mTOR is involved in control of longevity, also enhances reprogramming efficiency. In addition, the small molecules used to inhibit these pathways also significantly improved longevity in Drosophila melanogaster. We further tested the potential effects of six other longevity‐promoting compounds on iPSC induction, including two sirtuin activators (resveratrol and fisetin), an autophagy inducer (spermidine), a PI3K (phosphoinositide 3‐kinase) inhibitor (LY294002), an antioxidant (curcumin), and an activating adenosine monophosphate‐activated protein kinase activator (metformin). With the exception of metformin, all of these chemicals promoted somatic cell reprogramming, though to different extents. Our results show that the controllers of somatic cell reprogramming and organismal lifespan share some common regulatory pathways, which suggests a new approach for studying aging and longevity based on the regulation of cellular reprogramming.