蛋白质Wnt3能帮助大脑重返年轻

上一篇 / 下一篇  2011-08-27 12:07:41

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日本产业技术综合研究所近日发表公报说,运动可以刺激脑细胞合成一种名为Wnt3的蛋白质,而这种蛋白质能帮助大脑重返年轻。

公报说,大脑内掌管学习和记忆的海马区内有神经干细胞。人成年后,神经干细胞仍然能够不断产生新的神经细胞,保证海马区的神经细胞持续更新。不过,人步入老年后,海马区神经干细胞的细胞制造能力会逐渐减弱,大脑的各项功能也随之下降。

产业技术综合研究所的科研人员对比了年老实验鼠和年轻实验鼠在大脑海马区的星形胶质细胞的差异。星形胶质细胞是脑内神经胶质细胞的一种。

科研人员发现,年老实验鼠的星形胶质细胞生成蛋白质Wnt3的能力明显下降,只有年轻实验鼠的约三十分之一。科研人员猜测,Wnt3不足,可能就是大脑神经干细胞功能下降的原因。

在进一步的实验中,科研人员让年老实验鼠短时间跑步。锻炼后,实验鼠大脑产生Wnt3蛋白质的能力有了大幅度的提高。随之,大脑神经干细胞的活动也活跃起来。科研人员说,如果坚持锻炼,大脑就会重返年轻。

此次成果的论文将刊登于即将出版的《美国实验生物学联合会会志》(The FASEB Journal)上

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PMC:
PMID:

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

Masahiro Okamoto, Koshiro Inoue, Hiroki Iwamura, Kazuyuki Terashima, Hideaki Soya, Makoto Asashima and Tomoko Kuwabara

Many persistent pain states (pain lasting for hours, days, or longer) are poorly treated because of the limitations of existing therapies. Analgesics such as nonsteroidal anti-inflammatory drugs and opioids often provide incomplete pain relief and prolonged use results in the development of severe side effects. Identification of the key mediators of various types of pain could improve such therapies. Here, we tested the hypothesis that hitherto unrecognized cytokines and chemokines might act as mediators in inflammatory pain. We used ultraviolet B (UVB) irradiation to induce persistent, abnormal sensitivity to pain in humans and rats. The expression of more than 90 different inflammatory mediators was measured in treated skin at the peak of UVB-induced hypersensitivity with custom-made


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