日本在人耳中发现软骨干细胞

上一篇 / 下一篇  2011-08-26 11:17:07

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日本研究人员8月8日在美国《国家科学院院刊》(PNAS)网络版上发表论文说,他们在人耳中发现了可发育为软骨的干细胞

横滨市立大学教授谷口英树率领的研究小组,在对小耳症患者切除的耳软骨进行分析时发现,覆盖耳软骨的膜中存在一种特殊细胞,这一细胞具有发育为软骨等组织的干细胞性质。

研究人员成功在试管中将这种软骨干细胞培育为成熟软骨细胞,然后将其移植到实验鼠背部皮肤上,最后形成了软骨。这种再生软骨在实验鼠身上维持了约10个月。

研究小组认为,利用这一成果,今后在治疗鼻骨骨折、面部骨折等面部变形时,有望从患者耳中采集软骨干细胞,进行软骨细胞培养并移植到患者的腹部皮下脂肪,等软骨细胞发育成一定程度大小的软骨后,移植到患部。

研究人员计划在获得日本厚生劳动省批准后,最早明年开始临床研究

PMC:
PMID:

Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium

Kobayashi, Shinji; Takebe, Takanori; Inui, Midori; Iwai, Sayaka; Kan, Hiroomi; Zheng, Yun-Wen; Maegawa, Jiro; Taniguchi, Hideki

Despite the great demands for treating craniofacial injuries or abnormalities, effective treatments are currently lacking.One promising approach involves human elastic cartilage reconstruction using autologous stem/progenitor populations. Nevertheless,definitive evidence of the presence of stem cells in human auricular cartilage remains to be established. Here, we demonstratethat human auricular perichondrium, which can be obtained via a minimally invasive approach, harbors a unique cell population,termed as cartilage stem/progenitor cells (CSPCs). The clonogenic progeny of a single CD44+ CD90+ CSPC displays a number of features characteristic of stem cells. Highly chondrogenic CSPCs were shown to reconstruct large(>2 cm) elastic cartilage after extended expansion and differentiation. CSPC-derived cartilage was encapsulated by a perichondriumlayer, which contains a CD44+ CD90+ self-renewing stem/progenitor population and was maintained without calcification or tumor formation even after 10 mo. Thisis a unique report demonstrating the presence of stem cells in auricular cartilage. Utilization of CSPCs will provide a promisingreconstructive material for treating craniofacial defects with successful long-term tissue restoration.


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