LC/MS分析血清中小分子样品净化方法

前言：

The removal of matrix interferants from biological samples using off-line SPE adds a time-consuming step to analytical separations. On-line sample clean-up utilizing SEC minimizes the number of steps, minimizes the total time required for analysis and has the added advantage that it can be automated.

结论：

• This poster successfully demonstrates the use of on-line SEC for the extraction of analytes from serum.

• On-line SEC analysis provides a suitable alternative to off-line SPE for the clean-up of samples in biological matrices.

• The methodology is robust and reproducible.

• Unlike off-line SPE, the process can be automated