监测早期产品配方中的阴离子和阳离子

前言：Development of methods for the simultaneous analysis of active pharmaceutical ingredients and their counter-ion salts.

仪器：Thermo Scientific Dionex UltiMate 3000 RSLC system

结论：A full screening method was able to simultaneously resolve 5 active counter ions of over 25 commonly used pharmaceutical re-evaluated here to test its applicability as discovery to confirm salt formation and stoichiometry optimization. In this study many of the same chosen along with 9 APIs as various salts). pharmaceutical ingredients along with 18 common counter-ions. This method was then modified into shorter methods for calculation of counter-ion content. A more advanced on-line cleanup method was also used to analyze the sodium released from a commercially available pain relief tablet with results within 2% of the expected value.