制药应用手册-阴离子,阳离子,有机酸和碳水化合物

Table of Contents
Index of Analytes.......................................................................................................................................................................3
Introduction to Pharmaceuticals................................................................................................................................................4
UltiMate 3000 UHPLC+ Systems.............................................................................................................................................5
IC and RFIC Systems................................................................................................................................................................6
MS Instruments.........................................................................................................................................................................7
Chromeleon 7 Chromatography Data System Software...........................................................................................................8
Process Analytical Systems and Software................................................................................................................................9
Automated Sample Preparation..............................................................................................................................................10
Analysis of Anions, Cations, Organic Acids, and Carbohydrates....................................................................................11
Determination of Transition Metals in Serum and Whole Blood by Ion Chromatography ..................................................12
Determination of Trifluoroacetic Acid (TFA) in Peptides......................................................................................................17
Quantification of Anions in Pharmaceuticals.........................................................................................................................23
Determination of Inorganic Anions and Organic Acids in Fermentation Broths....................................................................31
Determination of Residual Trifluoroacetate in Protein Purification Buffers and Peptide Preparations
by Reagent-Free Ion Chromatography............................................................................................................................42
Assay for Citrate and Phosphate in Pharmaceutical Formulations Using Ion Chromatography...........................................49
Direct Determination of Cyanate in a Urea Solution and a Urea-Containing Protein Buffer................................................56
Determination of Inorganic Anion Impurities in a Water-Insoluble Pharmaceutical
by Ion Chromatography with Suppressed Conductivity Detection.................................................................................64
Quantification of Carbohydrates and Glycols in Pharmaceuticals.........................................................................................71
The Determination of Carbohydrates, Alcohols, and Glycols in Fermentation Broths..........................................................79
Determination of Inorganic Counterions in Pharmaceutical Drugs Using Capillary IC........................................................89
Determination of Galactosamine Containing Organic Impurities in Heparin by HPAE-PAD
Using the CarboPac PA20 Column..................................................................................................................................91
Determination of Oversulfated Chondroitin Sulfate and Dermatan Sulfate in Heparin Sodium
Using Anion-Exchange Chromatography with UV Detection.........................................................................................99
A Faster Solution with Increased Resolution for Determining Chromatographic Identity
and Absence of OSCS in Heparin Sodium.....................................................................................................................107
Column Selection Guide.....................................................................................................................................................113
Thermo Scientific Acclaim Column Selection Guide...........................................................................................................114
Transferring HPLC Methods to UHPLC..........................................................................................................................115
Easy Method Transfer from HPLC to RSLC with the Dionex Method Speed-Up Calculator............................................116