高通量LC-MS/MS进行代谢物稳定性分析

前沿

High throughput screening (HTS) assays are commonly used in the discovery stage of the drug development process where a large number of compounds are screened. Compound optimization and sample analysis are factors that limit throughput. This study addresses mass spectrometry optimization and sample analysis problems by using the Aria TLX-4 multiplexed HPLC system, powered by TurboFlow™ technology, and Thermo Scientific QuickQuan software for the compound optimization process.

仪器：

Thermo Scientific TSQ Quantum Ultra triple quadrupole mass spectrometer

结论：

The combination of an Aria TLX-4 HPLC system, QuickQuan software and a Thermo Scientific TSQ Quantum Ultra triple quadrupole mass spectrometer significantly increases sample throughput without compromising quality.