使用TSQ Quantum鉴定人体生物样品中LSD及其代谢产物

前言:

Lysergic acid diethylamide (LSD) is a very potent hallucinogenic drug involving, particularly, behavioral disorders and is also extensively metabolized in man. Moreover, LSD and its major metabolites are present at low concentration in biological fluids, such as whole blood or urine. Identification and quantitation of such compounds, often performed during a classical forensic expertise, necessitate a sensitive and specific method. This study aims to describe a method using liquid chromatography/ tandem mass spectrometry and permitting to quantify LSD and its metabolites at low concentrations.

仪器:

Thermo Scientific TSQ Quantum mass spectrometer

结论:

This application note described a sensitive, specific method developed for the quantitation of lysergide and metabolites in various biological matrices.