药品应用手册--管控药

Table of Contents
Index of Analytes........................................................................................................................................................................4
Introduction to Pharmaceuticals.................................................................................................................................................5
UltiMate 3000 UHPLC+ Systems.............................................................................................................................................6
IC and RFIC Systems.................................................................................................................................................................7
MS Instruments..........................................................................................................................................................................8
Chromeleon 7 Chromatography Data System Software...........................................................................................................9
Process Analytical Systems and Software...............................................................................................................................10
Automated Sample Preparation...............................................................................................................................................11
Analysis of Controlled Drugs................................................................................................................................................12
Determination of Bethanechol by Ion Chromatography.........................................................................................................13
Determination of Nevirapine Using HPLC with UV Detection.............................................................................................17
Determination of Carbachol In Ophthalmic Solutions Using a Reagent-Free Ion Chromatography System.......................24
Determination of Verapamil Hydrochloride Purity Using the Acclaim PA Column..............................................................32
Determination of Glucosamine in Dietary Supplements Using HPAE-PAD.........................................................................36
Determination of Urea and Allantoin in Cosmetics Using the Acclaim Mixed-Mode HILIC Column.................................45
Analysis of Sumatriptan in Cerebro-spinal Fluid Using Capillary LC/MS/MS.....................................................................51
Budesonide and Related Substances on Acclaim 300 C18.....................................................................................................53
Glucocorticosteroids in Serum on Acclaim 120 C18..............................................................................................................54
Propafenone and Related Substances Using Acclaim PA........................................................................................................55
Loperamide in Anti-diarrhea Tablets on Acclaim 120 C8.......................................................................................................56
Simultaneous Analysis of a Basic Drug and Its Counterion (Trimipramine).........................................................................57
Simultaneous Separation of Bisoprolol and Its Counterion Fumarate....................................................................................58
Rapid Separation of Paclitaxel and Related Compounds in Palitaxel Injection.....................................................................60
Separation of Etoposide Using an Acclaim Phenyl-1 Column...............................................................................................63
UHPLC Separation of Nine Corticosteroids in Under Four Minutes.....................................................................................65
Determination of Methacholine Chloride and Potential Impurities
Using a Reagent-Free Ion Chromatography System........................................................................................................69
HPLC Assay Method for Drug Products Containing Anti-Tuberculosis Active Pharmaceutical Ingredients.......................77
Sensitive and Fast Determination of Endothall in Water Samples by IC-MS/MS.................................................................88
Mass Spectrometry Compatible Separation of Itraconazole and Related Substances by UHPLC........................................94
Determination of Ethyl Sulfate Impurity in Indinavir Sulfate Drug Using Ion Chromatography.......................................100
Evaluation of the USP Risedronate Sodium Assay...............................................................................................................105
Column Selection Guide......................................................................................................................................................113
Thermo Scientific Acclaim Column Selection Guide...........................................................................................................114
Transferring HPLC Methods to UHPLC..........................................................................................................................115
Easy Method Transfer from HPLC to RSLC with the Dionex Method Speed-Up Calculator............................................116