Bruker introduces an entirely new mass spectrometry technology platform: the innovative timsTOF™ system combines very high ion mobility resolution using Bruker’s proprietary Trapped Ion Mobility Spectrometry (TIMS) with Bruker’s ultra-high performance QTOF mass spectrometry, an innovative, highly flexible instrument for optimal separation and analysis of yet unresolved critical compounds. Bruker’s unique Ion Mobility Expansion (imeX™) TIMS technology empowers market-leading, highest ion mobility resolution that can be adjusted to any research or analytical needs. A novel Open Data Format supports user-created software tools tailored to specific research questions.

In recent years, ion mobility separation has matured into a valuable analytical tool that boosts mass spectrometry analysis in various research areas. The ion mobility resolution, however, has been restricted in previous IMS systems by physical size limitations. Bruker’s completely unique and proprietary timsTOF system eliminates these trade-offs and limitations with the extremely powerful, yet very compact TIMS device that achieves market-leading ion mobility resolution greater than 200 for unparalleled separation power.

Learn more

Bruker introduces rapifleX™, the highest performance MALDI-TOF/TOF mass spectrometer, which had been shown as work-in-progress to early adopters at HUPO 2015. The rapifleX is by far the most advanced TOF/TOF system today, and was re-designed from the ground up with focus on speed, robustness and confidence to meet today’s highest demands for in-depth intact and top-down protein characterization, and high-performance, high-throughput mass spectrometry imaging (MSI). The rapifleX TOF/TOF is well-suited for detailed protein characterization in life science research and biopharmaceutical laboratories. In addition, the rapifleX extends the MALDI Tissuetyper® imaging capabilities with rapid, spatially resolved MS/MS data. Learn more

The new rapifleX MALDI PharmaPulse solution is the latest addition to Bruker’s portfolio of innovative products designed to assist pharmaceutical, biotech and CRO customers to accelerate drug discovery. Based on the new 10 kHz laser rapiflex™ MALDI-TOF system, and incorporating an integrated automation solution, this is the first mass-spectrometry based, label-free uHTS (ultra-high throughput screening) solution, using standard 1,536 microtitre plates, or even 6,144 plates. The rapifleX MALDI PharmaPulse solution analyses a 1,536 MTP in < 8 minutes, and due to its extreme robustness it is suitable for primary screens of millions of compounds, with significantly lower cost per sample. Its label-free detection of substrates and products accelerates assay development, reduces complexity of screening, and potentially minimizes artifacts from interferences with the labels used in traditional uHTS technologies. Learn more

Bruker introduces – in collaboration with Professor Gary Siuzdak of the Scripps Center for Metabolomics – its new mass spectral library MetaboBASE Personal Library which contains MS/MS spectra of over 13,000 metabolic compounds acquired from Bruker high-resolution, accurate mass QTOF instruments, allowing fast, automated identification and dereplication of known compounds.

Learn more

We were very pleased to host you at the ASMS conference this year. We hope you have perceived ASMS 2016 worthwhile your visit, have gained new insights and have found the time for engaging discussions.

As always, our goal at Bruker is to provide you with regular updates about these new technologies, innovative analytical methods and our latest scientific contributions. Therefore, you can download the posters we presented at ASMS 2016 and also read up about the product launches in our ASMS Media Room.

Learn more

Bruker will be presenting at Antibody-based Bio-therapeutics Asian Forum in Shanghai on July, 13-15. Find out about latest technologies and innovative analytical methods at our Booth 12 and oral talk, 3rd Floor, InterContinental Shanghai Pudong Hotel, China.

Click here to learn more

The tertiary structure of therapeutic proteins is key to their activity and stability. Due to the complexity of these proteins and the fact that they will contain multiple disulfide bonds, analysis is a challenge – often requiring several LC/MS runs with the tryptic digests from reduced and non-reduced protein and a manual comparison of these two analyses. The DisulfideDetect workflow allows the fully automated analysis of disulfide bonds in biopharmaceuticals, based on a single digest of the unreduced protein and without prior knowledge of enzyme specificity or native disulfide bonds. The workflow provides a semi-quantitative scrambling analysis as well.

Click here to learn more.

Chemokines are important for a number of diseases, including cancer metastasis. Dr Christian Bleiholder, Assistant Professor of Chemistry and Biochemistry, Florida State University, discusses how Bruker’s timsTOF™ system enables him to resolve different conformations of transport proteins to elucidate the role of chemokines in cells trafficking within the immune system.

Click here to stream the video.

How have the interactions of macromolecules in organisms evolved over eons? To find out, Cuihong Wan and Blake Borgeson-then both working at the Center for Systems and Synthetic Biology at the University of Texas at Austin-used various forms of mass spectrometry (MS) to study protein complexes across a wide range of organisms in search of protein – protein interactions that have endured as organisms evolved.

Click here to read the full article.

We are happy to announce the launch of Bruker’s new blog dedicated to Mass Spectrometry. More than a company supplying mass spectrometers and accompanying solutions, we are a team of passionate and curious people who want to push boundaries, explore ideas and trigger the productive exchange of perspectives that fuels science. This blog is a forum where we share the excitement that makes us go to work every day, the reasons why we always aim to do things better. Dive in and join the conversation!

Click here to get to MASS^perSPEC^tive.

On our Webinar Portal you and your customers can stream all of our webinars live and on-demand:

Upcoming Webinar:

• July 26^th: Applications of GC–MS-MS and LC-Ion Trap MS-MS in Postmortem Forensic Toxicology

On-Demand:

• June 28^th: Streamlining Drug Development: Native LC-MS for Rapid Screening and Drug Product QC Release Testing of Antibody Drug Conjugates
• June 28^th: Structure Elucidation with Trapped Ion Mobility Spectrometry
• June 16^th: Uncovering Metabolic Pathways in Disease to Support Drug Discovery Using High Resolution MALDI Imaging Mass spectrometry
• June 16^th: Rapid and Sensitive Quantitation of Approximately 100 Synthetic Cannabinoids In Serum by UHPLC-Triple Quadrupole Mass Spectrometry
• May 17^th: Biosynthetic Function of Genes in Plants and Their Consequences in Insects– a Metabolite Profiling Approach Driven by Automatic Compound Identification