性能参数
质量范围(线性):1 - 500 kDa
(反射):1 - 70 kDa
质量分辨率:
线性:6000 FWHM;
反射:25,000 FWHM
MS/MS:10,000 FWHM
离子门(Ion gate)分辨率:500 FWHM
灵敏度:
线性(肽段):100 amol (靶上)
线性(蛋白):100 fmol (靶上)
反射:100 amol (靶上)
MS/MS :500 amol (靶上)
质量准确度
线性:20 ppm 内标;100 ppm外标*
反射:2 ppm 内标;20 ppm外标*
MS/MS: 50 ppm
*zei邻近的外标,30分钟内
所有以上性能指标,使用通用的不锈钢靶和标准测试样品获得
激光器
固态超快UV激光器 Solid-state ultra fast UV laser
真正2,000 Hz激光,用于MS和MS/MS采集 True 2 kHz laser for both MS and MS/MS acquisitions
355 nm波长 355 nm wavelength
可变聚焦:10 μm ~ >100 μm Variable focus from 10 μm to >100 μm
最大脉冲速率:2 kHz(每秒2000个点)Maximum pulse rate 2 kHz (2000 shots per second)
可变脉冲速率:1 Hz ~2000 Hz Variable pulse rate from 1 Hz to 2000 Hz
Near-normal (on-axis) incidence of the laser beam to the sample
Technical Data
Sample Handling
10 plate loader sample handling system
Up to 10 microtiter plate format MALDI plates
XY stage (10 μm step, 10 μm repeatability) for microtiter plate footprint MALDI target
Accepts FlexiMass-DS? disposable polymeric and FlexiMass-SR? steel reusable microscope slide format with optional Precision? Adaptor
Option to store plates in the 10 plate loader in an inert atmosphere (N2 gas) to protect more sensitive samples
Software-driven target stage for accurate positioning of the sample under the laser focus
Fully automated raster software for scanning samples with circular or rectangular rasters
Fuzzy raster: automatic laser dithering on each laser position
Sample Viewing System
State-of-the-art high-definition viewing optics
Full HD colour picture (1080p)
10 μm resolution sample viewing
Software-controlled variable focus, adapted to viewing different sample surfaces
Crystal clear image enhanced by long-life LED illumination
Ionization Source
Matrix assisted laser desorption ionization
Pulsed extraction (mass calibrated variable delay under software control)
Variable ion extraction energy (linear up to +/-20 kV, reflectron up to+/-20 kV)
Positive and negative ion operation, as standard, through software selection
Unique wide-bore ion optics to minimize source contamination
TrueClean – software-driven UV laser-based source cleaning to reduce the need for maintenance
Laser
Solid-state ultra fast UV laser
True 2 kHz laser for both MS and MS/MS acquisitions
355 nm wavelength
Variable focus from 10 μm to >100 μm
Maximum pulse rate 2 kHz (2000 shots per second)
Variable pulse rate from 1 Hz to 2000 Hz
Near-normal (on-axis) incidence of the laser beam to the sample
Analyzer
Linear flight tube of 2.1 m drift length
Reflectron effective path length: 4.1 m
Vacuum maintained by 2 turbomolecular pumps with rotary backing
Unique curved-field reflectron system permitting 20 keV laboratory frame energy CID without reacceleration
Beam blanking to deflect unwanted high intensity signals e.g. matrix ions
Unique high resolution dual wire-grid ion gate allowing isolation of adjacent precursor ions
Collision cell (20 keV high energy CID MS/MS) fully optimized for fragmentation efficiency and ultimate sensitivity
Software-controlled helium gas introduction for high-energy CID MS/MS
Differentially pumped collision cell using turbomolecular pump with rotary backing and collision gas purge
Fragmentation further enriched by retaining all of the metastable decay ions through the analyzer
ASDF– Axial Spatial Distribution Focussing – for 10 000 resolution of MS/MS fragment ions
MS/MS resolution essentially independent of laser intensity and sample topography
Detectors
Linear mode: electron multiplier
Reflectron mode: ultra fast electron multiplier
Control and Data System*
Computer: dual/multi core workstation class with 8 GB RAM
Monitor: widescreen
500 GB hard disk
Network adaptor
Microsoft Windows 7 operating system
*minimum requirements subject to continuous improvement
Software Environment
MALDI Solutions? software – operates under 64 bit Microsoft Windows 7
Software for fully automated data generation using the experiment queue for LC-MALDI in combination with the 10 plate loader
Define, acquire and view experiments from the instrument
Create experiments and review results using MALDI Solutions from any computer on the user's network
Manual acquisition mode for full control of the instrument
Full data export to industry standard (imzML, mzML)
Multi-user environment with fully configurable security
User-specific access/restriction to experiments and results
Centralized secure database for experiment and data storage
Full audit trail, allows for 21 CFR part 11 compliance
Software Functionality
LC-MALDI acquisition software for proteomics
MALDI imaging software for tissue imaging
Calculator for determining theoretical masses
Software for automatic setting of the precursor ion gate and acquisition of
MS/MS spectra
Scanning function for the identification of 'sweet spots' to maximize results obtained from individual samples
Sample target design editor
Sample raster design editor
Tools to generate peak lists and access internet or intranet protein database search engines (Mascot? from Matrix Science)Installation Data
Dimensions
Size (w x h x d) – 2.84 m x 1.2 m x 1.3 m, minimum distance to wall at back is 100 mm
Weight – 875 kg
Installation Requirements
Electrical – 200 VAC, 50/60 Hz, 15 A single phase OR– 230 VAC, 50/60 Hz, 15 A single phase
A 'clean', stable and continuous mains supply is required for reliable operation
Temperature – ambient 18° to 28° Celsius
Relative humidity – less than 70% non-condensing
Vibration free, firm, level floor, at least 1000 kg supported at eight points
Gas supply: 99.995% helium collision gas
Tubing for gas installation (suitable coil provided): stainless steel 3 mm OD,0.7 mm wall thickness, pressure regulated at 3 bar?
Regulator equipped with a suitable adaptor to accept 3 mm OD stainless steel tubing + safety release<5 bar
Collision cell (20 keV high energy CID MS/MS) fully optimized for fragmentation efficiency and ultimate sensitivity
Software-controlled helium gas introduction for high-energy CID MS/MS
Differentially pumped collision cell using turbomolecular pump with rotary backing and collision gas purge
Fragmentation further enriched by retaining all of the metastable decay ions through the analyzer
ASDF– Axial Spatial Distribution Focussing – for 10 000 resolution of MS/MS fragment ions
MS/MS resolution essentially independent of laser intensity and sample topography
Detectors
Linear mode: electron multiplier
Reflectron mode: ultra fast electron multiplier
Control and Data System*
Computer: dual/multi core workstation class with 8 GB RAM
Monitor: widescreen
500 GB hard disk
Network adaptor
Microsoft? Windows? 7 operating system
*minimum requirements subject to continuous improvement
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