中国药科大学药物代谢研究中心生物大分子室
400-6699-117转1000
承担项目
| 项目名称 |
起止时间 |
项目来源 |
| 药物对膜转运蛋白功能和基因表达的影响及其在药动学研究中的应用 | 2005.1~2007.12 | 国家自然科学基金 |
| 基因重组人胰岛素吸入粉雾剂研制的关键技术与应用 | 2007.9~2010.12 | 国家863项目 |
| 临床前药代动力学关键技术及平台研究 | 2004.1~2007.12 | 科技部重大专项 |
| 中药复方制剂中有效成分的肠吸收机制及其口服剂型方案的研究 | 2005.1~2007.12 | 国家自然科学基金重大专项 |
| 生物技术药物体内吸收、代谢、分布的新模型与新理论研究 | 2000.1~2003.12 | 国家自然科学基金 |
| 建立中药复方多组分药代动力学研究方法及模型 | 2002.1~2003.12 | 国家中医药管理局科技专项 |
| 一类新药1215的药代动力学研究 | 2004.1-12 | 企业 |
| 一类中药新药H203的药代动力学研究 | 2005.1-12 | 企业 |
| 银杏内酯B动物药代动力学试验 | 2006.1-12 | 企业 |
| 一类新药胡黄连苷的药代动力学研究 | 2007.5-12 | 企业 |
论文及专著
近年发表论文：
2008年
1. Qiao-Ling Yu, Ying Zhao, Xi-Jing Chen, Zi-Dong Gao, Wei-Chao Ren, Hui He, Jing Jing. A Sensitive LC–ESI–MS Method for Pharmacokinetic Studies of Picroside II in Dog Plasma. Chromatographia. 2008, 67: 1013–1016 [Download]
2. Jing Jing, Weichao Ren, Xijing Chen, YueWang, Qiaoling Yu, Guangji Wang, Andrew K. Davey, Jiping Wang and Ning Jing. Glucuronide-sulfate Diconjugate as a Novel Metabolite of Glycyrrhetic Acid in Rat Bile. Drug Metab Pharmacokinet. 2008, 23 (3): 175–180 [Download]
3.Jing DONG, Xue YU, Lei WANG, Ye-bin SUN, Xi-jing CHEN, Guang-ji WANG.Effects of cyclosporin A and itraconazole on the pharmacokinetics of atorvastatin in rats.Acta Pharmacologica Sinica 2008 October; 29 (10): 1247-1252
2007年
1. Xijing Chen, Hui He, Guangji Wang, Bing Yang, Weichao Ren, Le Ma and Qiaoling Yu. Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies. Biomed Chromatogr. 2007, 21: 257–265
2. Xijing Chen, Jing Jing, Weichao Ren, De-en Han, Ning Jing, Guangji Wang.Determination of 5-aminoimidazole-4-carboxamide in human plasma by ion-pair extraction and LC–MS/MS. Journal of Chromatography B. 2007, 855: 140–144
3. Jing Jing, Weichao Ren, Xijing Chen, Hui He, Wei Zhou, Xuping Zhu, Ya Sun and Guangji Wang. Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS. Biomed Chromatogr. 2007, 21: 836–840
4. Ying Zhao, Desheng Zhai, Xijing Chen, Jinnan Yang, Xiangfeng Song, Hui He, Qiaoling Yu, Yan Xing. Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats. Toxicology 2007, 230 : 145–150
5. Hui He, Ying Zhao, Xijing Chen, Yuanting Zheng, Xiaolan Wu, Rui Wang , Tingting Li , Qiaoling Yu, Jing Jing, Le Ma, Weichao Ren, Deen Han, Guangji Wang. Quantitative determination of trans-polydatin, a natural strong anti-oxidative compound, in rat plasma and cellular environment of a human colon adenocarcinoma cell line for pharmacokinetic studies. Journal of Chromatography B. 2007, 855: 145–151
6. Desheng Zhai, Ying Zhao, Xijing Chen, Jiqiang Guo, Hui He, Qiaoling Yu, Jinnan Yang, Andrew K Davey, Jiping Wang. Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats. Planta Med. 2007, 73: 128-133
7. Ying Zhao, Desheng Zhai, Xijing Chen, Hui He, Qin Lu and Qiaoling Yu. Protective effect of glycyrrhizin and matrine on acute vanishing bile duct syndrome induced by alpha naphthylisothiocyanate in rats. Hepatology Research. 2007, 37: 143–151
8. Le Ma, Jing Dong, Xinjing Chen, Guangji Wang. Development and Validation of Atorvastatin by LC-ESI-MS and Application in Bioequivalence Research in Healthy Chinese Volunteers. Chromatographia. 2007,65: 737-741
近年出版著作
