抗肿瘤药物研究实验室
400-6699-117转1000
丁克博士简介
丁克博士，中科院广州生物医药与健康研究院研究员，博士生导师。丁克博士1995年本科毕业于中国药科大学，并于1998年获中国药科大学药物化学硕士学位。2001年获复旦大学有机化学博士学位(师从中科院上海有机化学研究所马大为教授)。2001年12月-2005年2月在美国密西根大学从事博士后研究。2005年3月任美国密西根大学医学院Research Inivestigator。2006年3月回国加入中科院广州生物医药与健康研究院。现任中科院广州生物医药与健康研究院、广州呼吸疾病国家重点实验室研究员。
丁克博士已在国际权威学术期刊如： “J. Am. Chem. Soc.”、 “J. Med. Chem.” 、“Org. Letts”等发表论文近20篇，并发表会议论文近十篇。此外，他还作为主要发明人申请国际、国家专利多项。部分专利已成功转让美国药物开发公司。
论文发表选录：
1. Ding, Ke; Lu, Yipin; Nikolovska-Coleska, Zaneta; Wang, Guoping; Qiu, Su; Shangary, Sanjeev; Gao, Wei; Qin, Dongguang; Stuckey, Jeanne; Krajewski, Krzysztof; Roller, Peter P.; Wang, Shaomeng. Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2-p53 Interaction. Journal of Medicinal Chemistry (2006), 49(12), 3432-3435. J. Med. Chem. 杂志2006 年度下载率最高的论文之一(Most-Accessed Articles)。并被选为 J. Med. Chem. 杂志 2007年1~6月份期刊的封面文章。
2. Ding, Ke; Lu, Yipin; Nikolovska-Coleska, Zaneta; Qiu, Su; Ding, Yousong; Gao, Wei; Stuckey, Jeanne; Krajewski, Krzysztof; Roller, Peter P.; Tomita, York; Parrish, Damon A.; Deschamps, Jeffrey R.; Wang, Shaomeng. Structure-Based Design of Potent Non-Peptide MDM2 Inhibitors. Journal of the American Chemical Society (2005), 127(29), 10130-10131.
3. Ding, Ke; Chen, Jianyong; Ji, Min; Wu, Xihan; Varady, Judith; Yang, Chao-Yie; Lu, Yipin; Deschamps, Jeffrey R.; Levant, Beth; Wang, Shaomeng. Enantiomerically Pure Hexahydropyrazinoquinolines as Potent and Selective Dopamine 3 Subtype Receptor Ligands. Journal of Medicinal Chemistry (2005), 48(9), 3171-3181.
4. G. Tang, K. Ding, Z. Nikolovska-Coleska, C.-Y. Yang, S. Qiu, S. Shangary, R. Wang, J. Guo, W. Gao, J. Meagher, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, and S. Wang. Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins. Journal of Medicinal Chemistry (2007), ASAP(pubs.acs.org)
5. Ding, Ke; Wang, Guoping; Deschamps, Jeffrey R.; Parrish, Damon A.; Wang, Shaomeng. Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition. Tetrahedron Letters (2005), 46(35), 5949-5951.
6. Ding, Ke; Wang, Shaomeng. Efficient synthesis of isoflavone analogues via a Suzuki coupling reaction. Tetrahedron Letters (2005), 46(21), 3707-3709.
7. Ma, Dawei; Jiang, Yongwen; Chen, Fangping; Gong, Li-Kun; Ding, Ke; Xu, Yong; Wang, Renxiao; Ge, Aihua; Ren, Jin; Li, Jingya; Li, Jia; Ye, Qizhuang. Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted g -Keto Carboxylic Acids. Journal of Medicinal Chemistry (2006), 49(2), 456-458.
8. Chen, Jianyong; Ding, Ke; Levant, Beth; Wang, Shaomeng. Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility. Bioorganic & Medicinal Chemistry Letters (2006), 16(2), 443-446.
9. Ji, Min; Chen, Jianyong; Ding, Ke; Wu, Xihan; Varady, Judith; Levant, Beth; Wang, Shaomeng. Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands. Bioorganic & Medicinal Chemistry Letters (2005), 15(6), 1701-1705.
10. Ding, Ke; Flippen-Anderson, Judy; Deschamps, Jeffrey R.; Wang, Shaomeng. An efficient synthesis of optically pure (S)-2-functionalized 1,2,3,4-tetrahydroquinoline. Tetrahedron Letters (2004), 45(5), 1027-1029.
11. Ke Ding and Dawei Ma. Asymmetri synthesis of a,a-disubstituted amino acids by diastereoselective functionalization of enantiopure phenyloxazinone, derivatives of asymmetric Strecker reaction products of aldehydes. Tetradetron. (2001), 57(30), 6361-6366.
12. Dawei Ma and Ke Ding. Synthesis of enantiopure a,a-disubstituted amino acids from asymmetric Strecker reaction products of aldehydes. Organic Letters. (2000), 2(16), 2515-2517.
13. Ma, Dawei; Ding, Ke; Tian, Hongqi; Wang, Baomin; Cheng, Dongliang. Asymmetric synthesis of (S)-1-aminoindan-1,5-dicarboxylic acid and related analogues via intramolecular acylation of enantiopurea ,a -disubstituted amino acids. Tetrahedron: Asymmetry (2002), 13(9), 961-969.
14. Shangary S, Ding K, Qiu S, Nikolovska-Coleska Z, Lu YP, McEachern D, Wang SM Mechanism of action and therapeutic potential of a new, promising non-peptide small-molecule inhibitor (MI-43) of the p53-MDM2 interaction. CLINICAL CANCER RESEARCH (2005), 11 (24): 9145S-9146S.
15. Zhang M, Ling Y, Yang CY, Liu H, Wang R, Wu X, Ding K, Zhu F, Griffith BN, Mohammad RM, Wang S, Yang D. A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)–induced apoptosis in leukemia cells. Ann Hematol. 2007, 86(7): 471-81.
16. Ke Ding, Xinrong Zhang, Dawei Ma and Baomin Wang. Synthesis and biological activity of 1-aminoindan-1,3-dicarboxylic acid, a benzo analogue of (1S, 3 R) ACPD. Chinese Journal of Chemistry. (2001), 19(12), 1232-1238.
专利情况：
1. Wang, Shaomeng; Ding, Ke; Tang, Guozhi; Wang, Renxiao; Yang, Chao-Yie; Nikolovska-Coleska, Zaneta. Preparation of chromen-4-ones as inhibitors of anti-apoptotic BCL-2 family members for treatment of cancer. PCT Int. Appl. (2006), 92pp. WO 2006099193.
2. Wang, Shaomeng; Ding, Ke; Lu, Yipin; Nikolovska-Coleska, Zaneta; Qiu, Su; Wang, Guoping; Qin, Dongguang; Shangary, Sanjeev. Preparation of spirotryprostatin A derivatives as inhibitors of MDM2. PCT Int. Appl. (2006), 216pp. WO 2006091646。
3. Ma, Dawei; Ding, Ke; Wu, Wengen; Li, Jia. Preparation of 2-arylsulfonyltetrahydroisoquinoline hydroximic acid derivs. as matrix metalloproteinase inhibitors. Faming Zhuanli Shenqing Gongkai Shuomingshu (2002), 24 pp. CN 1380288。授权号CN 1187332C
4. Ma, Dawei; Ding, Ke; Ye, Qizhuang; Li, Jia. Preparation of alkynylaryloxoalkanoates as matrix metalloproteinase inhibitors. Faming Zhuanli Shenqing Gongkai Shuomingshu (2002), 17 pp. CN 1380279。授权号CN 1169768C
5. Wang, Shaomeng; Varady, Judith; Wu, Xihan; Min, Ji; Ding, Ke; Levant, Beth. Preparation and evaluation of fused pyrazinoquinolines as dopamine receptor ligands. PCT Int. Appl. (2002), 136 pp. WO 2002100350。
