结论

基于对本研究中氟喹诺酮化合物的特征离子化的观察，使用UPLC IMS MS^E进行方法开发是合理的。

  ■ 使用离子淌度，可将同一分子，不同质子化物质实现神奇的分离。

  ■ 显示并鉴别了同分子，不同位点质子化合物的碎片谱图。

  ■ 得到每个组分的母离子MS及其MS^E碎片谱图

  ■ HDMS^E观察结果可以解释在同一实验室内监测特定MRM离子队获得的研究对象报告结果有时 会出现差异的原因。

  ■ 漂移时间值可作为保留时间、母离子精确质量数和碎片精确质量数谱图之外的又一个鉴定条件。

  ■ 离子淌度分离可以有效地将目标峰从基质干扰中分离出来，而不需要对复杂样品进行纯化及色谱分离。

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