QTRAP代表文献回顾
生物分子发表的代表性文献
QTRAP：同时具有三重四极杆和线性离子阱性能的独一无二的LC/MS/MS系统
QTRAP系统最早在ASMS 2002上，作为第一台商用的线性离子阱发布，是世界上唯一的线性离子阱和三重四极杆的复合串联液质联用系统。QTRAP具有独一无二的能力，可以运行蛋白质组学和生物标志物研究的完整工作流。比如其翻译后修饰（PTM）发现工作流，将目标物的三重四极杆式扫描（母离子扫描，真正的中性丢失扫描，和多反应监测MRM），同高灵敏度的离子阱MS/MS扫描结合在一起，可进行靶向的、灵敏度更高的翻译后修饰分析。使用MRM和MIDAS流程，可进行目标物检测和定量。该流程革新了对翻译后修饰（如磷酸化和糖基化修饰）的研究，在包括人血浆在内的复杂混合物中可进行蛋白/多肽的检测/定量。
下列技术文献并不是包括QTRAP的所有文献的罗列，它是一个文献的回顾，回顾那些使用QTRAP技术获得突破性发现和前沿生物研究的最佳文献。
1. Technology 技术
1.1. A new linear ion trap mass spectrometer
Author: Hager JW
Year: 2002
Journal: Rapid Communications in Mass Spectrometry
Volume: 16
Pages: 512-526
1.2. Product ion scanning using a Q-q-Qlinear ion trap (QTRAP) mass spectrometer.
Author: Hager JW, Le Blanc JCY
Year: 2003
Journal: Rapid Communications in Mass Spectrometry
Volume:17
Pages: 1056 -1064
1.3. Unique scanning capabilities of a new hybrid linear ion trap mass spectrometer (QTRAP) used for high sensitivity proteomics applications.
Author: Le Blanc JCY, Hager JW, Ilisiu AMP, Hunter C, Zhong F, Chu I.
Year: 2003
Journal: Proteomics
Volume: 3
Pages: 859-869
1.4. Resonant Excitation in a Low Pressure Linear Ion Trap
Author: Collings BA, Stott WR, Londry FA.
Year: 2003
Journal: J. Am. Soc. Mass Spectrometry
Volume: 14
Pages: 622-634
1.5. Product ion spectral simplification using time-delayed fragment ion capture with tandem linear ion traps.
Author: Hager JW.
Year: 2003
Journal: Rapid Communications in Mass Spectrometry
Volume: 17
Pages: 1389-1398
1.6. Mass selective axial ion ejection from a linear quadrupole ion trap.
Author: Londry, FA, Hager JW.
Year: 2003
Journal: J. Am. Soc. Mass Spectrometry
Volume: 14
Pages: 1130-1147
1.7. High-performance liquid chromatography-tandem mass spectrometry with a new quadrupole/linear ion trap instrument.
Author: Hager JW, Le Blanc JCY.
Year: 2003
Journal: J. Chromatography A
Volume: 1020
Pages: 3-9
1.8. QTRAP mass spectrometer technology for proteomics applications.
Author: Hager JW
Year: 2004
Journal: DDT: TARGETS
Volume: 3
Pages: S31-S36
1.9.Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules (Tutorial).
Author: Hopfgartner G, Varesio E, Tschappat V, Grivet C, Bourgogne E, Leuthold, LA.
Year: 2004
Journal: Journal of Mass Spectrometery
Volume: 39
Pages: 845-855
1.10. Multiple precursor ion monitoring – a new scan strategy on hybrid quadrupole/.linear ion trap mass spectrometers? (Letter to the Editor).
Author: Rogalski JC, Lin S, Kast J.
Year: 2004
Journal: Rapid Communications in Mass Spectrometry
Volume: 18
Pages: 739-741
1.11. AP and Vacuum MALDI on a QqLIT Instrument.
Author: Schneider BB, Lock C Covey, TR.
Year: 2005
Journal: J. Am. Soc. Mass Spectrometry
Volume: 16
Pages: 176-182
1.12. Multiple Neutral Loss Monitoring (MNM): A Multiplexed Method for Post-Translational Modification Screening.
Author: Hoffman MD, Sniatynski MJ, Rogalski JC, Le Blanc JCY, Kast J.
Year: 2006
Journal: J. Am. Soc. Mass Spectrom.
Volume: 17
Pages: 307-317
1.13. MS/MS of Ions in a Low Pressure Linear Ion Trap Using a Pulsed Gas.
Author: Collings BA, Romashin MA.
Year: 2009
Journal: J. Am. Soc. Mass Spectrom.
Volume: 20
Pages: 1714-1717
2. Phosphorylation – Precursor Ion Scanning 磷酸化——母离子扫描
2.1. SKAR is a specific target of S6 kinase 1 in cell growth control.
Author: Richardson CJ, Broenstrup M, Fingar DC, Julich K, Ballif BA, Gygi S, Blenis J.
Year: 2004
Journal: Current Biology
Volume: 14
Pages: 1540-1549
2.2.Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
Author: Auld GC, Campbell DG, Morrice N, Cohen P
Year: 2005
Journal: Biochem J.
Volume: 389
Pages: 775-783.
2.3. Substrate Specificity and Activity Regulation of Protein Kinase MELK.
Author: Beullens M, Vancauwebergh, Morrice N, Derua R, Ceulemans H, Waelkens E, Bollen M.
Year: 2005
Journal: Journal Biological Chemistry
Volume: 280
Pages: 40003-40011
2.4. Automated Identification and Quantification of Protein Phosphorylation Sites by LC/MS on a Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometer.
Author: Williamson BL, Marchese J, Morrice NA
Year: 2006
Journal: Molecular Cellular Proteomics
Volume: 5.2
Pages: 337-346
2.5. Characterization of the reversible phosphorylation and activation of ERK8.
Author: Klevernic IV, Stafford MJ, Morrice NA, Peggie M, Morton S, Cohen P.
Year: 2006
Journal: Biochemical Journal
Volume: 394
Pages: 365-373
2.6. Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation.
Author: Goransson O, Deak M, Wullschelger S, Morrice N, Prescott AR and Alessi DR.
Year: 2006
Journal: Journal Cell Science
Volume: 119
Pages: 4059-4070
2.7. A Quantitative Results-driven Approach to Analyzing Multisite Protein Phosphorylation.
Author: Zappacosta, F, Collingwood TS, Huddleston MJ, Annan RS
Year: 2006
Journal: Molecular Cellular Proteomics
Volume: 5.11
Pages: 2019-2030
2.8.dDYRK2 and Minibrain interact with the chromatin remodeling factors SNR1 and TRX.
Author: Kinstrie R, Lochhead PA, Sibbet G, Morrice N, Cleghon V
Year: 2006
Journal: Biochemal Journal
Volume: 398
Pages: 45-54
2.9. Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
Author: Stafford MJ, Morrice NA, Peggie MW, Cohen P.
Year: 2006
Journal: FEBS Letters
Volume: 580
Pages: 4010-4014
2.10. A Chaperone-Dependent GSK3.
Transitional Intermediate Mediates Activation-Loop
Autophosphrylation.
Author: Lochhead PA, Kinstrie R, Sibbet G, Rawjee T, Morrice N, Cleghon V.
Year: 2006
Journal: Molecular Cell
Volume: 24
Pages: 627-633
2.11. Selective detection and identification of phosphopeptides by dansyl MS/MS/MS fragmentation.
Author: Amoresano A, Monti G, Cirulli C, Marino G.
Year: 2006
Journal: Rapid Comm. Mass Spectrom.
Volume: 20
Pages: 1400 1404
2.12. The Drosphila p21 activated kinase Mbt modulates DE-cadherin mediated cell adhesion by phosphorylation of Armadillo.
Author: Menzel N, Melzer J, Waschke J, Lenz C, Wecklein H, Lochinit G, Drenckhahn D, Raabe T.
Year: 2008
Journal: Biochem J.
Volume: 416
Pages: 231-241
2.13. Functional Proteomics Identifies Targets of Phosphorylation by B-Raf Signaling in Melanoma
Author: Old WM, Shabb JB, Houel S, Wang H et al.
Year: 2009
Journal: Cell
Volume: 34
Pages: 115-131
3. Phosphorylation – MIDAS. Workflow 磷酸化——MIDAS工作流
3.1. Multiple Reaction Monitoring as a Method for Identifying Protein Posttranslational Modifications
Author: Cox DM, Zhong F, Du M, Duchoslav E, Sakuma T McDermott JC.
Year: 2005
Journal: Journal Biomolecular Technology
Volume: 16
Pages: 83-90
3.2. Multiple Reaction Monitoring to Identify Sites of Protein Phosphorylation with High Sensitivity.
Author: Unwin RD, Griffiths JR, Leverentz MK, Grallert A, Hagan IM, Whetton AD.
Year: 2005
Journal: Molecular & Cellular Proteomics
Volume: 4 (18)
Pages: 1134-1144
3.3. A sensitive mass spectrometric method for hypothesisdriven detection of peptide post-translational
modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS)
Author: Unwin RD, Griffiths JR, Whetton AD.
Year: 2005
Journal: Nature Protocols
Volume: 4 (6)
Pages: 870-877
3.4. Expanding the Genetic Code of Escherichia coli with Phosphoserine
Author: Park HS, Hohn MJ, Umehara T, Guo LT, Osborne EM, Benner J, Noren CJ Rinehart J, Soll D
Year: 2011
Journal: Sciense
Volume: 333
Pages: 1151-1154
4. Phosphorylation – MRM Quantitation 磷酸化——MRM定量
4.1. Analysis of phosphorylation sites on focal adhesion kinase using nanospray liquid
chromatography/multiple reaction monitoring mass spectrometry.
Author: Ciccimaro E, Hevko J, Blair IA.
Year: 2006
Journal: Rapid Communications Mass Spectrometry
Volume: 20
Pages: 3681-3692
4.2. Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.
Author: Wolf-Yadlin A, Jautanlemi S, Lauffenburger DA, White FM
Year: 2007
Journal: PNAS
Volume: 104
4.3. Systematic Discovery of In Vivo Phosphorylation Networks.
Author: Linding Rune et al.
Year: 2007
Journal: Cell
Volume: 129
Pages: 1-12
5. Glycosylation 糖基化
5.1. The Q-Trap mass spectrometer, a novel tool in the study of protein glycosylation.
Author: Sandra K, Van Beeumen J, Stals I, Claeyssens M
Year: 2004
Journal: J. Am. Soc. Mass Spectrometry
Volume: 15
Pages: 413-423
5.2. Characterization of cellobiohydrolase I N-glycans and differentiation of their phosphorylated isomers
by capillary electrophoresis – Q-Trap mass spectrometry.
Author: Sandra K, Van Beeumen J, Stals I, Sandra P, Claeyssens M, Devreese B
Year: 2004
Journal: Analytical Chemistry
Volume: 76
Pages: 5878-5886
5.3. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
Author: Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR
Year: 2004
Journal: Proteomics
Volume: 4
Pages: 454-465
5.4. Combining gel and capillary electrophoresis, nano-LC and mass spectrometry for the elucidation of post-translational modifications of Trichoderma ressei cellobiohydrolase
Author: Sandra K, Stals I, Sandra P, Claeyssens M, Van Beeumen J, Devreese B
Year: 2004
Journal: J. Chromatography A
Volume: 1058
Pages: 263-273
5.5. Specific detection of O-linked N-acetylhexosamine modified peptides using multiple precursor ion scans (Letter to the Editor).
Author: Rogalski JC, Kast J
Year: 2005
Journal: Rapid Communications in Mass Spectrometry
Volume: 19
Pages: 77-78
5.6. Elucidation of N-glycosylation sites on human platelet proteins – a glycoproteomic approach.
Author: Lewandrowski U, Moebius J, Walter U, Sickmann A.
Year: 2006
Journal: Molecular Cellular Proteomics
Volume: 5.2
Pages: 226-233
6. Glycosylation –NanoMate (Advion) 糖基化——NanoMate(Advion）
6.1. Characterization of Protein Glycosylation using Chip-based Nanoelectrospray with Precursor Ion Scanning Quadrupole Linear Ion Trap Mass Spectrometry.
Author: Zhang S, Williamson BL.
Year: 2005
Journal: Journal Biomolecular Techniques
Volume: 16
Pages: 209-219
7. Other Modifications 其它修饰
7.1. The Application of a Hypothesis-Driven Strategy to the Sensitive Detection and Location of Acetylated Lysine Residues.
Author: Griffiths JR, Unwin RD, Evans CA, Leech SH, Corfe BM, Whetton AD.
Year: 2007
Journal: J. Am. Soc. Mass Spectrom.
Volume: 18 (8)
Pages: 1423-1428
7.2. Targeted Mass Spectrometric Strategy for Global Mapping of Ubiquitin on Proteins.
Author: Mollah S, Wertz IE, Phung Q, Arnott D, Dixit VM, Lill JR
Year: 2007
Journal: Rapid Comm. Mass Spectrom
Volume: 21
Pages: 3357-3364
8. Protein Identification 蛋白鉴定
8.1. Snake venomics: characterization of protein families in Sistrurus barbouri venom by cysteine mapping, N-terminal sequencing and tandem mass spectrometry analysis.
Author: Jurarez P, Sanz L, Calvete JJ
Year: 2004
Journal: Proteomics
Volume: 4
Pages: 327-338
8.2. Proteomic analysis of small heat shock protein isoforms in barley shoots.
Author: A Süle, F Vanrobaeys,Gy Hajós, J Van Beeumen, B Devreese,
Year: 2004
Journal: Phytochemistry
Volume 65, Issue 12, June 2004, Pages 1853–1863
Proteomics 2
8.3.The application of 2-D dual nanoscale liquid chromatography and triple quadrupole-linear ion trap system for the identification of proteins.
Author: Tschappat V, Varesio E, Signor L, Hopfgartner G
Year: 2005
Journal: Journal Separation Science
Volume: 28
Pages: 1704-1711
8.4. The Hold Oak leaf proteome: Analytical and biological variability in the protein expression level assessed by 2DE and protein identification by tandem mass spectrometry and de novo sequencing and sequence similarity searching.
Author: Jorge I, Navarro RM, Lenz C, Ariza D, Porras C, Jorrin J.
Year: 2005
Journal: Proteomics
Volume: 5
Pages: 222-234
8.5. Cell wall proteins in apoplastic fluids of Arabidopsis thaliana rosettes: Identification by mass spectrometry and bioinformatics.
Author: Boudart G, Jamet E, Rossignol M, Lafitte C, Borderies G, Jauneau A, Esquerre-Tugaye MT, Pont-Lezica R
Year: 2005
Journal: Proteomics
Volume: 5
Pages: 212-221
8.6. Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410).
Author: Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O.
Year: 2005
Journal: Analytical Biochemistry
Volume: 345
Pages: 122-132
8.7. Proteomic Analysis of Pinus radiate Needles: 2-DE Map and Protein Identification by LC/MS/MS and Substitution-Tolerant Database Searching.
Author: Valledor L, Castillejo MA, Lenz C, Rodriguez R, Canal MJ, Jorrin J
Year: 2008
Journal: J. Proteome Res.
Volume: 7
9.Protein/Peptide MRM Quantitative Applications – Absolute Quant 蛋白/多肽MRM定量应用——绝对定量
9.1. Mass spectrometric quantitation of peptides and proteins using stable isotope standards and capture by anti-peptide antibodies (SISCAPA).
Author: Anderson NL, Anderson NG, Haines LR, Hardie DB, Olafson RW, Pearson TW
Year: 2004
Journal: Journal of Proteome Research
Volume: 3
Pages: 235-244
9.2. Relative and Absolute Quantitative Expression Profiling of Cytochromes P450 using Isotope-coded Affinity Tags.
Author: Jenkins RE, Kitteringham NR, Hunter CL, Webb SN, Hunt TJ, Elsby R, Watson RB, Williams D, Pennington SR,
Park BK.
Year: 2006
Journal: Proteomics
Volume: 6
Pages: 1934-1947
9.3. Use of a variably sensitive selected reaction monitoring method to extend the linear dynamic range for quantitative high-performance liquid chromatography / tandem mass spectrometry.
Author: Fries HE, Aiello M, Evans CA.
Year: 2007
Journal: Rapid Communications in Mass Spectrometry
Volume: 21
Pages: 369-374
9.4. Cyclostreptin binds covalently to microtubule pores and luminal taxoid binding sites.
Author: Buey RM et al.
Year: 2007
Journal: Nature Chemical Biology
Volume: 3(2)
Pages: 117-125
9.5. Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution.
Author: Keshishian H, Addona T, Burgess M, Kuhn E, Carr SA
Year: 2007
Journal: Mol. Cell. Proteomics
Volume: 6 (12)
Pages: 2212 – 2229.
9.6. Mass Spectrometric Detection of Attomole Amounts of the Prion Protein by nanoLC/MS/MS.
Author: Onisko, B, Dynin, I, Requena JR, Silva, CJ, Erickson M, Carter JM
Year: 2007
Journal: J. Am. Soc. Mass Spectrom
Volume: 18
Pages: 1070-1079.
9.7. Sensitive, preclinical detection of prions in brain by nanospray liquid chromatography / tandem mass spectrometry.
Author: Onisko, B, Silva, CJ, Dynin I, Erickson M, Vensel WH, Hnasko R, Requena JR, Carter JM
Year: 2007
Journal: Rapid Comm. Mass Spectrom.
Volume: 21
Pages: 4023-4026.
9.8. Critical roles for a genetic code alteration in the evolution of the genus Candida.
Author: Silva RM, Paredes JA, Moura GR, Mandas B, Lima-Costa T, Rocha R, Miranda I, Gomes AC, Koerkamp MJG,
Perrot M, Holstege FCP, Boucherie H, Santos MAS
Year: 2007
Journal: EMBO Journal
Volume: 15 (21)
Pages: 1-11.
9.9. Absolute Quantification of Monoclonal Antibodies in Biofluids by Liquid Chromatography-Tandem Mass Spectrometry
Author: Hagman C, Ricke D, Ewert S, Bek S, Falchetto R, Bitach F
Year: 2008
Journal: Anal Chem
Volume: 80
Pages: 1290-1296
9.10. Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Senstive Simultaneous LC/MS/MS Method Combined with Novel in-silco Peptide Selection Criteria.
Author: Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine U, Ochida Y, Ito S, Terasaki T
Year: 2008
Journal: Pharmaceutical Research
Volume: 25 (6)
Pages: 1469-1483
9.11. Doping control analysis of insulin and its analogues in equine plasma by liquid chromatography–tandem mass spectrometry
Author: Ho9 ENM, Wan TSM, Wong ASY, Lam KKH, Stewart BD
Year: 2008
Journal: J. Chrom A
Volume: 1201
Pages: 183-190
9.12. Multiple Reaction Monitoring of mTRAQ-Labeled Peptides Enables Absolute Quantification of Endogenous Levels of a Potential Cancer Marker in Cancerous and Normal Endometrial Tissues.
Author: DeSouza LV, Taylor AM, Li W, Minkoff MS, Romachin AD, Colgan TJ, Siu KWM
Year: 2008
Journal: J. Proteome Research
Volume: 7
Pages: 3525-3534.
9.13. Full Dynamic Range Proteome Analysis of S. cerevisiae by Targeted Proteomics.
Author: Picotti P, Bodenmiller B, Nueller LN, Domon B, Aebersold R.
Year: 2009
Journal: Cell
Volume: 138
Pages: 795-805
9.14. Multi-site assessment of the precision and reproducibility of MRM-based measurements of proteins in plasma.
Author: Addona T et al.
Year: 2009
Journal: Nature Biotech
Volume: 27 (7)
Pages: 633-641
9.15. Quantification of Cardiovascular Biomarkers in Patient Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution*
Author: Keshishian H, Adona T, Burgess M, Mani DR, Shi X, Kuhn E, Sabatine MS, Gerszten RE, Carr SA
Year: 2009
Journal: Mol Cell Proteomics
Volume: 8.10
Pages: 2239-2349
9.16. Multiple Reaction Monitoring-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma*
Author: Kuzyk MA, Smith D, Yang J, Cross TJ, Jackson AM, Hardie DB, Anderson NL, Borchers CH
Year: 2009
Journal: Mol Cell Proteomics
Volume: 8.8
Pages: 1860-1877
9.17. High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich a-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration
Author: Kay R, Barton C, Velloso CP, Brown PR, et al
Year: 2009
Journal: Rapid Comm Mass Spectr
Volume: 23
Pages: 3171-3181
9.18. Absolute Quantification of Potential Cancer Markers in Clinical Tissue Homogenates Using Multiple Reaction Monitoring on a Hybrid Triple Quadrupole/ Linear Ion Trap Tandem Mass Spectrometer
Author: Desouza LV, Romashin AD, Colgan TJ, Siu KWM
Year: 2009
Journal: Anal Chem
Volume: 81
Pages: 3462-3470
9.19. Determination of Protein Stoichiometry within Protein Complexes Using Absolute Quantification and Multiple Reaction Monitoring
Author: Schmidt C, Lenz C, Grote M, Luhrmann R, Urlaub H
Year: 2010
Journal: Anal Chem
Volume: 82
Pages: 2784-2796
10. Protein/Peptide MRM Quantitative Applications – Clinical Applications 蛋白/多肽MRM定量应用——临床
10.1. Quantification of C-reactive protein in the serum of patients with rheumatoid arthritis using multiple reaction monitoring mass spectrometry and 13C-labeled peptide standards. (API 3000)
Author: Kuhn E, Wu J, Karl J, Liao H, Zolg W, Guild B
Year: 2004
Journal: Proteomics
Volume: 4
Pages: 1175-1186
10.2. The Application of Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry to the Detection and Quantitation of Apolipoproteins in Human Serum.
Author: Kay RG, Gregory B, Grace PB, Pleasance S
Year: 2007
Journal: Rapid Commun. Mass Spectrom.
Volume: 21(16)
Pages: 2585-2593
10.3. Quantification of Thyroglobulin, a Low-Abundance Serum Protein, by Immunoaffinity Peptide Enrichment and Tandem Mass Spectrometry.
Author: Hoofnagle AN, Becker JO, Wener MH, Heinecke JW
Year: 2008
Journal: Clinical Chemistry
Volume: 54:11
Pages: 1796-1804.
10.4. Clinical quantitation of prostate specific antigen biomarker in the low nanogram/mL range by conventional bore liquid chromatography-tandem mass spectrometry (MRM) coupling and correlation with ELISA tests.
Author: Fortin R, Salvador A, Charrier JP, Lenz C, Lacoux X, Morla A, Choquet-Kastylevsky G, Lemoine J
Year: 2009
Volume: 8
Pages: 1006 -1015
11.Protein/Peptide MRM Quantitative Applications – MRM3 蛋白/多肽MRM定量应用——MRM3
11.1. Simultaneous selected reaction monitoring, MS/MS and MS3 quantitation for the analysis of pharmaceutical compounds in human plasma using chip-based infusion.
Author: Leuthold LA, Grivet C, Allen M, Baumert M, Hopfgartner G.
Year: 2004
Journal: Rapid Communications in Mass Spectrometry
Volume: 18
Pages: 1995-2000
11.2. Multiple Reaction Monitoring Cubed for Protein Quantitation at the Low Nanogram/Milliliter Level in Nondepleted Human Serum.
Author: Fortin R, Salvador A, Charrier JP, Lenz C, Bettsworth F, Lacoux X, Choquet-Kastylevsky G, Lemoine J
Year: 2009
Journal: Analytical Chemistry
Volume: 81
Pages: 9343-9352
11.3. Human platelets express OATP2B1, an uptake transporter for atorvastatin.
Author: NieBen J. Et al.
Year: 2009
Journal: Drug Metabolism Disposition
Volume: 37 (5)
Pages: 1129-37.
12.Protein/Peptide MRM Quantitative Applications – Relative Quant 蛋白/多肽MRM定量应用——相对定量
12.1. Quantitative Mass Spectrometric MRM Assays for Major Plasma Proteins.
Author: Anderson L, Hunter CL
Year: 2006
Journal: Molecular and Cellular Proteomics
Volume: 5.4
Pages: 573-588
12.2. High sensitivity detection of plasma proteins by multiple reaction monitoring of N-glycosites.
Author: Stahl-Zeng J, Lange V, Ossola R, Aebersold R, Domon B
Year: 2007
Journal: Molecular and Cellular Proteomics
Volume: 6(10)
Pages: 1809-1817.
12.3.Integrated Pipeline for Mass Spectrometry-Based Discovery and Confirmation of Biomarkers Demonstrated in a Mouse Model of Breast Cancer.
Author: Whiteaker JR et al.
Year: 2007
Journal: J. Proteome Res.
Volume: 6(10)
Pages: 3962 – 3975.
12.4. Quantification of Hemoglobin A2 by Tandem Mass Spectrometry.
Author: Daniel YA, Turner C, Haynes RM, Hunt BJ, Dalton RN
Year: 2007
Journal: Clinical Chemistry
Volume: 53.8
Pages: 1448-1454
12.5. Targeted quantitative analysis of Streptococcus pyogenes virulence factors by multiple reaction monitoring.
Author: Lange V, Malmstrom JA, Didion J, King NL, Johansson BP, Schafer J, Rameseder J, Wong CH, Deutsch EW,
Brusniak MY, Buhlmann P, Bjorck L, Domon B, Aebersold R
Year: 2008
Journal: Molecular Cellular Proteomics
Volume: 7.8
Pages: 1489-1500
12.6. Coupled Global and Targeted Proteomics of Human Embryonic Stem Cells during Induced Differentiation
Author: Yokum AK, Gratsch RE, Leff N, Strahler JR, Hunter CL, Walker AK, Michailidis G, Omenn GS, O’Shea KS,
Andrews PC
Year: 2008
Journal: Molecular Cellular Proteomics
Volume: 7.4
Pages: 750-767
12.7. Combination of Improved 18O Incorporation and Multiple Reaction Monitoring: A Universal Strategy for Absolute Quantitative Verification of Serum Candidate Biomarkers of Liver Cancer
Author: Zhao Y, Jia W, Sun W, Jin W, Guo L, Wei J, Ying W, Zhang Y, Xie Y, Jian Y, He F, Qian X
Year: 2010
Journal: J Proteome Research
Volume: 9
Pages: 3319-3327
12.8. Quantitative protein determination for CYP induction via LC-MS/MS
Author: Williamson BL, Purkayastha S, Hunter CL, Nuwaysir L, Hill J, Easterwood L, Hill J
Year: 2010
Journal: Proteomics
Volume: 11
Pages: 33-41
13. Reagents 试剂
13.1. C-Terminal Signal Sequence Promotes Virulence Factor Secretion in Mycobaterium tuberculosis.
Author: DiGiuseppe Champion PA, Stanley SA, Champoin MM, Brown EJ, Cox JS
Year: 2006
Journal: Science
Volume: 313
Pages: 1632-1636
14.Protein Analysis 蛋白分析
14.1. Nanoelectrospray ionization of protein mixtures: solution pH and protein pI.
Author: Pan P, Gunawardena HP, Xia Y, McLuckey SA
Year: 2004
Journal: Analytical Chemistry
Volume: 76
Pages: 1165-1174
15.Lipids -Characterization 脂质——表征
15.1. Rapid and selective identification of molecular species in phosphatidylcholine and sphingomyelin by conditional neutral loss scanning and MS(3).
Author: Houjou T, Ramatani K, Nakanishi H, Imagawa M, Shimizu T, Taguchi R
Year: 2004
Journal: Rapid Communications in Mass Spectrometry
Volume: 18
Pages: 3123-3130
15.2. Identification of phospholipids structures in human blood by direct-injection quadrupole-linear ion-trap mass spectrometry.
Author: Wang C, Yang J, Gao P, Lu X, Xu G.
Year: 2005
Journal: Rapid Communications in Mass Spectrometry
Volume: 19
Pages: 2443-2453
15.3. Focused lipidomics by tandem mass spectrometry.
Author: Taguchi R, Houjou T, Nakanishi H, Tamazaki T, Ishida M, Imagawa M, Shimizu T.
Year: 2005
Journal: Journal of Chromatography B
Volume: 823
Pages: 26-36
15.4. Identification of Phospholipid Structures in Human Blood by Direct-Injection Quadrupole-Linear Ion-Trap Mass Spectrometry.
Author: Wang C, Yang J, Gao P, Lu X, Xu G.
Year: 2005
Volume: 19
Pages: 2443-2453
15.5. Mass Spectrometric Characterization of Lipid-Modified Peptides for the Analysis of Acylated Proteins.
Author: Hoffman MD, Kast J.
Year: 2006
Journal: Journal Mass Spectrometry
Volume: 41
Pages: 229-241
16.Lipids – Characterization / Quantitation 脂质－表征/定量
16.1. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation.
Author: Baker PR, Schopfer FJ, Sweeney S, Freeman BA.
Year: 2004
Journal: Proc Natl Acad Science
Volume: 101
Pages: 11577-11582
16.2. Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry.
Author: Merriill Jr AH, Sullards MC, Allegood JC, Kelly S, Wang E.
Year: 2005
Journal: Methods
Volume: 36
Pages: 207-224
16.3. Analysis of polyunsaturated aminophospholipid molecular species using isotope-tagged derivatives and tandem mass spectrometry / mass spectrometry / mass spectrometry.
Author: Zemski Berry KA, Murphy RC.
Year: 2006
Journal: Analytical Biochemistry
Volume: 349
Pages: 118-128
17.蛋白与其它分子相互作用
17.1. Detection of Protein-RNA Crosslinks by NanoLC-ESI-MS/MS Using Precursor Ion Scanning and Multiple Reaction Monitoring (MRM) Experiments.
Author: Lenz C, Kuhn-Holsken E, Urlaub H.
Year: 2007
Journal: J Am Soc Mass Spectrom.
Volume: 18
Pages: 869-881
17.2. Bidimensional Tandem Mass Spectrometry for Selective Identification of Nitration Sites in Proteins.
Author: Amoresano A, Chiappetta G, Pucci P, D’Ischia M, Marino G.
Year: 2007
Journal: Anal. Chem.
Volume: 79(5)
Pages: 2109-2117
18.Review 综述
18.1. Review: Mass Spectrometry and Protein Analysis.
Author: Domon B, Aebersold R.
Year: 2006
Journal: Science
Volume: 312
Pages: 212-217
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Publication number: 1630210-01
