刚发现刚出版的英文专著Gas Biology Research in Clinical Practice，主编是两个日本京都的学者：
Yoshikawa, T. (Kyoto); Naito, Y. (Kyoto)。（很奇怪的是，关于氢气的章节，为什么没有就近请在东京日本医科大学的太田教授执笔，反而跑美国找Nakao教授来写，无论在学术水平和氢气本身的研究基础，前者都更合适，可能是考虑英语水平的问题。）
该著作中有关于氢气的内容。其中的第四篇是氢气的医学应用。作者是美国匹兹堡大学的Atsunori
Nakao，他写了本书的其中二篇，在第四篇全面介绍了氢气的研究进展。过去虽然有几本关于氢气生物学效应的书，但都是为宣传产品而写的商业味道很浓，虽然有一定科普价值，但都非常不严肃，学术价值非常小。现在这本专著是历史上首次把氢气的医学应用编写进来，具有十分重要的意义。
第四篇的题目是氢气和医学应用（Hydrogen and
Medical Application）。
中文摘要：大量基础和临床研究表明，氢气是一种重要的生理调节因子，在细胞和器官水平上，具有抗氧化、抗炎症和抗细胞凋亡的作用，对许多疾病具有治疗效果。最近，氢气被确定为气体信号分子（吹牛），类似一氧化氮和一氧化碳。利用氢气治疗疾病的给氢方式包括直接呼吸、饮氢气水或注射含氢气的溶液。本文将针对氢气治疗疾病的有关进展进行系统总结。氢气将对人类治疗疾病中发挥重大影响。这个内容好像与他们上次发表在Free Rad Res 上的综述基本一样。
Hydrogen and Medical
Application
Atsunori Nakao Department of Surgery, University of Pittsburgh Medical
Center, Pittsburgh, Pa., USA
A number of basic and clinical researches have revealed
that hydrogen is an important physiological regulatory factor with antioxidant,
anti- inflammatory and anti- apoptotic protective effects on cells and organs,
with properties to mitigate various disease status. Recently, hydrogen gas has
been identified as a signaling gas molecule like nitric oxide and carbon
monoxide. Therapeutic hydrogen has been applied by different delivery methods
including straightforward inhalation, drinking hydrogen dissolved in water and
injection with hydrogen- saturated saline. Herein, I summarize currently
available data regarding the protective role of hydrogen in medicine, provide an
outline of recent advances in research on the use of hydrogen as a therapeutic
medical gas in diverse
models of disease, and discuss the feasibility of hydrogen as a therapeutic
strategy. Hydrogen’s impact on therapeutic and preventive medicine could be
enormous in the future.
In 2007, it was demonstrated that molecular hydrogen
selectively reduces the levels of
hydroxyl radicals and peroxynitrite in vitro and also
exerts potent antioxidant activity
in an in vivo rat cerebral ischemia model [1]. Since
then, there has been accumulating
evidence that hydrogen can act as a selective scavenger
of hydroxyl radicals, and have
potent anti- inflammatory and antiapoptotic properties
[2].
Hydrogen is one very promising gaseous agent that has
come to the forefront
of research during the last few years. Previous studies
have shown that nitric oxide
(NO),
carbon monoxide (CO) and hydrogen sulfide (H2S)
have cytoprotective
effects in multiple experimental/clinical disease models
and recognized as ‘signaling
gas molecules’ for regulation of physiological functions.
Given the recent increasing
number of systems in which hydrogen is shown to mediate
beneficial effects, the functions of hydrogen are likely due, in part, to the
reactive oxygen species (ROS)-
scavenging properties of hydrogen. However, the
scavenging properties of hydrogen an overview on the role of various gaseous molecules in
health and disease The substantial biological importance of gaseous
mediators in various physiological-pathological conditions has been realized
only recently, but to date, the detailed mechanisms involved remain elusive. The
publication at hand contains 16 overviews written by a panel of experts who
summarize the current knowledge and provide fundamental insights into the roles
of gaseous molecules in signal transduction in biological systems. The first
part provides a comprehensive overview on gaseous mediators in health and
disease. In the second part, the medical application of various molecules such
as nitric oxide, carbon monoxide, hydrogen sulfide, hydrogen, acetone and
phytoncide are discussed. Furthermore, articles on skin gas biology and
Carbon-13 (13C), especially clinical applications of 13C-labeled substrate are
included. This book
provides valuable information not only for basic researchers in physiology and
biochemistry, but also for gastroenterologists and clinicians who wish to learn
more about the role of gaseous mediators.
另外Atsunori Nakao本书中也写了一章关于医用治疗气体的内容（Therapeutic Medical
Gas，没有考虑好怎么翻译。觉得“医用治疗气体”别扭）。
Therapeutic Medical Gas
Therapeutic medical gas is
pharmaceutical gaseous molecules which offer solutions to medical needs. In
addition to traditional medical gases including oxygen and nitrous oxide, a
number of medical gases have been recently discovered to play protective roles
in various disease conditions. In particular, nitric oxide, carbon monoxide and
hydrogen sulfide are found to be endogenously generated in the human body and
mediate signaling pathways as biological messengers, and are shown to have
potent cytoprotective effects. Herein, we summarize the recent advances of
therapeutic medical gas research and discuss their clinical feasibility,
typically such as nitric oxide, carbon monoxide, hydrogen sulfide, hydrogen,
xenon, helium and ozone. A recent increase in publications in the medical gas
field clearly indicates that there are significant opportunities for the use of
medical gases as therapeutic tools. It would be necessary to identify safety
concerns when using therapeutic gases along with potential side effects and
toxicity. Although further investigations are required, medical gas may provide
a huge impact as a novel and innovative therapeutic tool for unmet medical needs with
considerable health burdens.
What Is ‘Therapeutic Medical
Gas’?
The definition of ‘therapeutic medical
gas’ is the pharmaceutical gaseous molecules which are applied to the human body
for the purpose of a variety of medical conditions and producing other desirable
effects. It is no doubt that oxygen therapy to increase tissue oxygenation has been a
mainstream in critical care medicine. However, recent observations in
experimental and clinical studies clearly revealed the needs to provide
additional supplemental gases to patients with many etiologies. The list of
therapeutic medical gases has been growing continuously (table 1). Herein, we
discuss the recent advances in medical gas research and delivery mechanisms
including clinical application for special gases with recently discovered roles
as protective properties.
