2008年ASMS的综述：解析液质市场

ASMS 2008: new products and previews.

http://www.allbusiness.com/trends-events/conferences-conventions/11432335-1.html

Publication: Instrument Business Outlook
Date: Sunday, June 15 2008

这是看到网上的一篇报道，挺有意思。

The 56th American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics (ASMS) was held at the Denver, Colorado, convention center from June 1 to June 5. The ASMS meeting continued its trend of increasing attendance, which was up close to 2% to 6,569. The number of exhibitors dropped by 12 to 171 this year after increasing nearly 30% in 2007 (see IBO 6/15/07). Many of the exhibitors that were in attendance were more active than in previous years, with more end-users' meetings on the preceding weekend and five press conferences, in contrast to the three press conferences held at 2007's meeting.

讲的是2008年在美国丹佛召开的第56届ASMS会议。参加者为6569人，展商为171个。

This year's ASMS meeting featured more than 2,500 presentations, in addition to the many oral presentations, lunch meetings and working group meetings. The number of abstracts in nearly all major product categories was up from 2007 (see graph, page 8). The most dramatic increase was for Q-Trap, for which the number of abstracts mentioning the technique nearly doubled. However, this number was only slightly higher than In 2006. This year, there were more abstracts on GC/MS, triple quadrupole and FT-ICR than in the last five years, which is likely related to the increasing activities In the environmental and food industries.

有2500个演讲，QTrap发表的数量翻了近一倍，还有很多气质联用，三重四极杆和FT-IR的摘要。

Several of the major MS vendors introduced new instruments at the show this year, with an obvious focus on triple quadrupole and Q-TOF LC/MS systems. Some ASMS continued from page 1 of the new introductions, however, will not be ready to ship until 2009, demonstrating an eagerness on the part of some vendors to begin wooing potential customers quite early.

几个主要的质谱厂商发布了新仪器，大多数聚焦在三重四极杆和Q-TOF领域。

Thermo Fisher Scientific introduced two new systems at this year's ASMS, including an addition to its TSQ triple quadrupole LC/MS line, and an all-new LC/MS instrument based on the company's hugely successful Orbitrap mass analyzer. Thermo's new TSQ Vantage is positioned above the current Ultra and Access models of the TSQ product line, and has 10 times the sensitivity of the Ultra, according to the company, which is primarily due to its next-generation optics. The TSQ Vantage is priced to compete with upper-tier tandem LC/MS systems in the $400,000-$450,000 range, and is now shipping.

Thermo推出了两个新系统。TSQ Vantage三重四极杆液质，和使用了Orbrap技术的Exactive。TSQ Vantage定位在超高端的领域，比TSQ Ultra提高了10倍灵敏度，主要的贡献来源于离子传输光学部分的改进。TSQ Vantage的售价大致在40~50万美元。

Also introduced by Thermo at ASMS was the Exactive benchtop LC/ MS system, which is based around the Orbitrap mass analyzer, in contrast to Thermo's LTQ-Orbitrap and LTQ-FT, the Exactive is not a tandem system, which greatly lowers its price, but it can still provide MS/MS. In addition, the Exactive has the same HCD (higher collision decomposition) scanning capability of the LTQ-Orbitrap, but is a faster system, providing 10,000 resolution at 10 scans per second, or 100,000 resolution at 1 scan per second. Despite the fact that the Exactive is categorized as an FT/MS, it is priced and positioned to compete against LC-TOF and LC-Q-TOF instrumentation. The Exactive will be priced in the $250,000-$350,000 range and the first shipments are expected by October.

Thermo还推出了台式的包含Orbitrap分析器的Exactive仪器，因为它不是串联的仪器，所以大幅降低了价格，但其实，Exactive仍可以提供串联质谱MS/MS功能。除此之外，Exactive有和Orbi同样的HCD（高能碰撞解离）能力，但采集速度更快，可每秒获得10张10,000分辨率的谱图，或者每秒获得1张高达100,000分辨率的谱图。Exactive是同LC-TOF和LC-Q-TOF竞争的产品，价位大致在25~35万美元。

Thermo also introduced new software and consumables products. The Proteome Discoverer proteomics analysis software, which will replace the company's Bioworks software, enables the comparison of MS data from a multitude of sources and comes with a SEQUEST license. Introducing a new labeling technology for protein quantitation, Thermo Scientific released the TMT Isobaric Mass Tagging Kits, based on technology exclusively licensed from Proteome Sciences.

Thermo还推出了新软件和耗材产品。Proteome Discoverer蛋白质组学分析软件，将取代公司的Bioworks软件，可对来自不同来源处的质谱数据进行比对。Thermo还推出了用于蛋白质定量的新的标记技术，TMT同位素质量标签解决方案包。

Bruker introduced an all-new high-end LC/MS Q-TOF system that is built to achieve high-resolution along with high-speed. The new maXis system has a resolution of 40,000-60,000 when scanning at 20 spectra per second, and a 1 ppm mass accuracy for both MS and MS/MS, according to Bruker. Despite being a very tall floor-standing system, the maXis is designed to take up a very small footprint, and operates on standard single-phase power. Bruker's primary competitive target for the maXis is Thermo's LTQ-Orbitrap product line. The starting US list price for the maXis is $575,000 and it is expected to begin shipping in September. One other item of note from Bruker at ASMS was its announcement of a GC-APCI interface for its micrOTOF II LC/MS TOF instrument, which was introduced at Pittcon (see IBO 3/15/08). This is a new direction for Bruker, as the company has not actively developed or marketed products for the GC/MS market before.

Bruker公司推出了新的高端Q-TOF，可获得高分辨和高速度。新的maXis系统具有40,000 ~ 60,000的分辨率，同时可每秒采集20张谱图，不管对MS还是MS/MS，都可获得1 ppm的质量精度。maXis是立式的，虽然很高，但是占地很小，也仅需要标准的单相供电。maXis是专门针对Orbitrap的竞争产品，起价定在57.5万美元。Bruker还推出了GC-APCI接口，用于其micrOTOF II LC/MS 飞行时间质谱。这是Bruker公司的一个新方向，即也开始挺进GC/MS市场。

Agilent introduced a trio of new instruments at ASMS, including a triple quadrupole LC/MS, an LC/MS QTOF and a triple quadrupole GC/MS. Agilent's 6460 is a new addition to its 6400 Series triple quadrupole LC/MS product line, which has been wildly successful since Agilent's recent entrance into this market segment. The 6460 features subfemtogram sensitivity, thanks largely to Agilent's new Jet Stream technology for enhancing the ionization and nebulization processes, which is an integrated part of the system. The Jet Stream technology also features prominently on Agilent's new 6530 LC/MS Q-TOF system, which is the third model in the 6500 product line. Agilent claims the 6530 has better than 50,000 resolution when run at 20 scans per second. US pricing for the 6460 starts at $350,000, and pricing for the 6530 starts at $505,000. Both models are set to begin shipping this September.

Agilent推出了三重四极杆液质、Q-TOF液质，和三重四极杆气质。6460是加入6400系列的一款新型三重四极杆液质，特点是：由Jet Stream喷射粒子流技术产生的fg级灵敏度，该技术提高了离子化和雾化效率。Jet Stream技术同时也用于Agilent的6530 Q-TOF液质系统，该系统具有超过50,000的分辨率，同时可每秒采集20张谱图。6460在美国起价为35万美元，6530起价为50.5万美元。

Also new from Agilent at the show was its 7000A triple quadrupole GC/MS. The system marks Agilent's entry into the triple quadrupole GC/ MS market, and makes it the fourth major competitor in the segment (see IBO 2/29/08). The 7000A is heavily based on Agilent's 5975C GC/MSD in terms of both external feel, the interface for the user, the quartz quadrupole mass analyzer and other internal components of the system. This was a very early preview of the system, as Agilent does not expect to begin shipping the 7000A until January 2009. Pricing has yet to be determined, but is expected to be between $200,000 and $250,000. Agilent also announced its new Triple Axis detector for the 5973 GC/MSD, which is also available as an upgrade to existing systems at a price between $3,000 and $4,000.

Agilent还推出了7000A三重四极杆的气质联用，意味着Agilent成为该类型仪器的第4家供应商（其余包括：Waters、Varian和Thermo）。7000A基于Agilent的5975C 气质联用技术，石英四极杆质量分析器、外部、内部组件和用户界面都类似，虽然价格还未公布，但预期其价格将在20~25万美元。Agilent也发布了用于5973 GC/MSD的三轴检测器，价格大概为3000~4000美元。

Waters introduced a new high-end triple quadrupole LC/MS, as well as its own version of an external column nanoLC system. Waters' new Xevo, its next-generation triple quadrupole LC/MS, has selected by IBO as this year's best new product at ASMS (see page 6). The Xevo makes use of a novel CID (collision-induced dissociation) technology that incorporates Waters' Scanwave technology, which provides additional selectivity. Waters intends for the Xevo to eventually replace its successful Quattro Premier XE. The Xevo is priced starting near $450,000 and is expected to begin shipping in the third quarter. Also new from Waters at the show was the Trizaic UPLC, which is a tile-based nanoscale HPLC system. The Trizaic combines Waters' UPLC technology with individual tiles that act as cartridges or chips that include a nanoscale column. ASMS was a preview of the Trizaic, which is not expected to ship until early 2009.

Waters发布了新型高端三重四极杆液质，和它自己的连接外部色谱柱的纳升级液相系统。推出的Xevo是一代新型三重四极杆液质，被IBO评选为年度最佳产品。Xevo使用新型CID技术，并结合了Waters的Scanwave技术，提供了更多的选择性。Waters希望最终Xevo取代它成功的Quattro Premier XE产品。Xevo的起价为45万美元。Waters还推出了Trizaic UPLC，是一台纳升级的液相，并采用了Waters UPLC的技术，包括管朱、芯片、纳升级流速的柱子。

Among other major MS vendors, Shimadzu had rolled out a revamped line of MALDI-TOF instruments earlier this year at Pittcon, but did not promote them heavily at ASMS. The line consists of the AXIMA Performance reflectron MALDI TOF/TOF MS for C1D MS/MS, the AXIMA Confidence reflectron MALDI-TOF MS and the AXIMA Assurance linear MALDI-TOF MS. Applied Biosystems introduced a host of new software products that are generally targeted at nonexperts and designed for ease of use.

在其它的主要质谱供应商中，岛津公司展示了其在当年Pittcon上发布的MALDI-TOF，但没有在ASMS上重点推广。这条MALDI-TOF线包括其AXIMA MALDI TOF/TOF质谱仪，AXIMA MALDI TOF反射型质谱仪，和AXIMA MALDI TOF线型质谱仪。AB公司介绍了其一系列新软件，这些软件主要为非专家级的用户设计，使其易于使用。

There were very few other introductions of systems or major related equipment. The recently created 1st Detect division of Spacehab showed its new Miniature Mass Spectrometer, which is based on the same ion trap technology that Spacehab developed for NASA. The new system weighs less than 15 lbs, has a mass range of 1-300 amu and MS" capability. 1st Detect plans to market the system to the military and first responders. The system will be available in the third quarter with a price point of well under $50,000.

Spacehab展示了其小型质谱，它和Spacehab为NASA（美国宇航局）设计的离子阱质谱是类似的。新的系统不到15磅重，质量范围1~300 amu。Spacehab公司希望该仪器售给军方和快速反应部门。这台小型质谱的售价将低于5万美元。

ASMS 2008 Product of the Show

IBO has selected Waters' new Xevo triple quadrupole LC/MS as the best new product from this year's ASMS meeting. While this new benchtop system certainly has a modern look, consistent with its name, it is the collision cell technology on the inside that made IBO take notice.

Waters公司的Xevo三重四极杆液质被IBO评为2008年度ASMS最佳新产品。这套台式的系统外观时尚，其内部独有的碰撞池技术使IBO选择了它。

The Xevo's novel collision cell design enables it to operate in T-Wave mode or in Waters' more recently developed ScanWave mode. T-Wave mode utilizes a stacked-ring ion guide design that allows it to produce a traveling wave that accelerates ions into the second quadrupole mass analyzer. This has the effect of significantly improving the fast scanning abilities of a tandem MS.

Xevo的新型碰撞池设计使它可操作在T-Wave模式或新的ScanWave模式下，T-Wave模式使用了堆叠的环形离子透镜技术，可以产生一种Traveling的行波来加速离子进入第二个四极杆分析器。该技术可显著提高串联质谱的扫描速度。

Perhaps the more interesting capability is the ScanWave mode of the collision cell, which functions as a sort of ion trap. In ScanWave mode, ions are accumulated and then selectively gated into the second quadrupole. This helps the Xevo to significantly increase the signal intensity of both parent and product ion spectra. In comparison to Waters' current state-of-the-art triple quadrupole LC/MS, the Quattro Premier XE, Waters claims that the Xevo attains as much as eight times the response as a result of the new collision cell design.

更有趣的是碰撞池的ScanWave模式，很像一个离子阱。在ScanWave模式下，离子被累积并选择性地进入第二个四极杆。这使Xevo显著提高了母离子和子离子的响应信号。而比较Waters自己成功的三重四极杆液质Quattro Premier XE，Waters说它的Xevo由于新的碰撞池设计，其信号响应是Quattro Premier XE的8倍。

While the collision cell is the centerpiece of the new Xevo, other improvements have been included as well. The system features Waters' IntelliStart technology, which was first introduced on the lower-end SQD and TQD LC/MS systems. It is intended to automate much of the instrument checks and calibration needed for operation. Waters clearly hopes to put a much more powerful LC/MS system in the hands of non-mass spectroscopists. The Xevo also features the latest generation of Waters' ZSpray ionization source, which is an integrated design that allows users to switch between various sources without any tools.

碰撞池技术的改变是核心，Waters还有其它的一些技术提高。比如智能开启（IntelliStart ）技术，第一次引入到其较低端的SQD和TQD液质中。这项功能可以自动完成大部分的仪器操作前的自检和校正功能。Waters显然希望将其LC/MS技术推给更多的非质谱专家。Xevo也具有最新一代的ZSpary离子化技术，这是一套集成的设计，使用户可以无需工具地在各种不同的离子源间切换。

The new Xevo appears to be a significant improvement in the triple quadrupole LC/MS market and should help position Waters regain some of the ground it lost in the segment several years ago. Waters intends to price the Xevo at or slightly above current top-end triple quadrupole LC/MS systems that are currently on the market.

新的Xevo是三重四极杆液质市场上的一个显著提高，帮助Waters收复几年前丢掉的部分市场，Waters想把Xevo定位在比最高端三重四极杆液质还高一点的价位。