Peptide-Based Drug Design: Methods and Protocols (Methods in Molecular
Biology)
By Laszlo Otvos
Publisher: Humana Press
Number Of Pages: 304
Publication Date: 2008-09-12
ISBN-10 / ASIN: 1588299902
ISBN-13 / EAN: 9781588299901
Binding: Hardcover
Product Description:
Due to their high specificity and low toxicity profile, peptideshave once
again become central to the development of new drugs. InPeptide-Based Drug
Design: Methods and Protocols, expert researchersprovide a handbook which offers
a selection of research and productiontools suitable for transforming a
promising protein fragment orstand-alone native peptide into a pharmaceutically
acceptablecomposition. The volume delves into contemporary, cutting-edge
subjectssuch as hit isolation and target validation, computer-aided
design,sequence modifications to satisfy pharmacologists, in vivo stabilityand
imaging, and the actual production of difficult sequences. Writtenin the highly
successful Methods in Molecular Biology™ series format,chapters include readily
reproducible, step-by-step laboratoryprotocols, lists of materials, and the
Notes section, which highlightstips on troubleshooting and avoiding known
pitfalls.
Comprehensive and up-to-date, Peptide-Based Drug Design: Methodsand Protocols
shows its subject to be an independent science on therise, and provides
scientists with a clear, concise guide forcontinuing this vital research.