在SELECT SERIES MRT高分辨质谱上用DESI XS 离子源进行质谱成像

DESI XS 环境离子源提供了很好的空间分辨率，在非常有限的样品制备条件下获得了高质量的小鼠脑组织切片分子图像。这与SELECT SERIES MRT相结合，使17种推测的脂质种类的定位具有极好的质量精确度（<400 ppb RMS）。SELECT系列MRT的分辨率>200,000 FWHM，显示了定位脂质的能力，质量准确度高达81 mDa，揭示了以前看不到的分子细节。这种高性能的成像系统是一个重要的步骤，在可视化的空间分布的信心确定的分子物种。

The DESI XS ambient ion source provided excellent spatial resolution resulting in high quality molecular images of mouse brain tissue sections with very limited sample preparation. This in combination with the SELECT SERIES MRT enabled the localization of 17 putative lipid species with superb mass accuracy (<400 ppb RMS). The >200,000 FWHM resolving power of the SELECT SERIES MRT demonstrated the ability to localize lipids differing by only 81 mDa, revealing previously unseen molecular detail. This high performance imaging system constitutes a significant step forward in visualizing the spatial distributions of confidently identified molecular species.