徕卡推出用于活细胞成像的DMi8 S

概述

最新产品包括一个Synapse实时控制器，用于收集更精细的时间分辨数据。

徕卡推出了DMi8 S，被描述为一个完整的解决方案，可以对活细胞进行快速、多功能的显微成像。

带有LASX Navigator的DMi8 S允许研究人员快速创建高分辨率的概述，例如，整个小鼠大脑。

这有助于在样本上定位，并容易发现关键区域以供进一步检查。

用多色免疫荧光标签扫描小鼠脑组织的图像。[中国厦门大学生命科学学院魏默博士]

徕卡微系统公司总裁马库斯·卢瑟说：“活细胞成像是未来的发现。了解动态过程是理解人类疾病的机制、潜在治疗和预防的关键。”。“这些新开发的DMi8具有深远的实用价值。无论是研究神经科学、癌症还是免疫学，研究人员都可以使用DMi8来获得他们问题的难以捉摸的答案，并找到与我们复杂生物学的联系。”

徕卡的DMi8 S成像解决方案提供了5倍的速度，并增加了高达10000X的观看面积。

这可以与新的光操作扫描仪相结合，在一次实验中激活、消融和漂白。

对于超分辨率和纳米级，增加了无限TIRF，可以同时进行单分子分辨率的多色成像。

这让研究人员能够看到更多、更快，并找到隐藏的东西，开启了宽场成像的下一个篇章。

DMi8 S的核心是一个新添加的Synapse实时控制器，使用户能够更快地获取数据，并收集更精细的时间分辨数据。

此外，新的LAS X Navigator是一个功能强大的GPS风格的概览工具，可以可视化所有类型的样本，包括幻灯片、盘子和多孔板。

徕卡利用DMi8 S的模块化无限端口结构，通过无限TIRF和无限扫描仪增加了先进的荧光功能。

通过Infinity TIRF模块，研究人员可以同时执行多色EPI、Hi Lo和TIRF照明，以及GSD/dSTORM和PALM等超分辨率应用的高功率照明选项。

Infinity Scanner photomanipulation模块为用户提供了前所未有的多模式能力，可以使用可光激活和可光切换荧光蛋白的最新发展。

研究人员现在可以通过在一个实验中执行光漂白、光转换、光遗传学和消融等任务，直接与活细胞互动并启动活细胞中的事件。

Leica launches DMi8 S for live cell imaging

Overview

Latest product includes a Synapse real-time controller for gathering finer time-resolved data.

Leica has introduced the DMi8 S, described as a complete solution for fast, versatile microscopic imaging of living cells. 

The DMi8 S with LASX Navigator allows researchers to quickly create high resolution overviews of, for example, the whole mouse brain. 

This facilitates orientation on the sample and easy discovery of critical regions for further examination. 

Tile scan image of Mouse brain tissue with multi-colour immunofluorescent labelin. [Dr. Wei Mo, School of Life Sciences, Xiamen University, China]

"Live-cell imaging is the future in discoveries. Gaining insight on dynamic processes is key to understand the mechanisms, potential treatments and prevention of human diseases," says Markus Lusser, President of Leica Microsystems. "These new DMi8 S developments have far reaching utility. Whether studying neuroscience, cancer, or immunology, researchers can use the DMi8 S to get elusive answers to their questions and find the links to our complex biology."

The DMi8 S imaging solution from Leica provides 5x more speed, and an increased viewing area up to 10,000x. 

This can be combined with the new photomanipulation scanner to activate, ablate, and bleach within one experiment. 

For super resolution and nanoscopy, the Infinity TIRF has been added allowing simultaneous multi-colour imaging with single molecule resolution. 

This allows researchers to see more, see faster, and find the hidden, opening up the next chapter in widefield imaging. 

At the heart of the DMi8 S is a newly added Synapse real-time controller that enables users to get their data more quickly and gather finer time-resolved data. 

In addition the new LAS X Navigator is a powerful GPS style overview tool to visualize all types of samples including slides, dishes and multi well plates. 

Utilizing the modular Infinity Port architecture of the DMi8 S, Leica has added advanced fluorescence capabilities with the Infinity TIRF and the Infinity Scanner. 

With the Infinity TIRF module, researchers can execute simultaneous multicolor EPI, Hi-Lo and TIRF illumination as well as a high power illumination option for super resolution applications like GSD/ dSTORM and PALM. 

The Infinity Scanner photomanipulation module gives users an unprecedented multimodal ability to use the latest developments in photoactivatable and photo switchable fluorescent proteins. 

Researchers can now interact directly with and initiate events in living cells by performing a combination of tasks like photobleaching, photoconversion, optogenetics and ablation within a single experiment.