Biosensing仪器推出全球首款用于膜蛋白相互作用研究的商用表面等离子体共振显微镜系统

发布时间： Feb 22， 2017

亚利桑那州坦佩--（美国商业资讯生物传感仪器公司（BI）推出了SPRm 200，这是世界上第一个商用表面等离子体共振显微镜（SPRM）系统。新型 SPRm 200 是市场上唯一可实现无标记的科学解决方案体外测量单个细胞在其天然环境中的结合反应和动力学。通过提供使用传感器芯片上生长的细胞研究分子相互作用的能力，这个新颖的系统重新定义了SPR技术的前沿。研究人员现在可以简单地选择一个细胞，并直接使用一台仪器进行结合亲和力和动力学研究。

“许多学术实验室一直在开发SPR系统，以获得更多关于膜蛋白的生物学相关结合信息，但自制解决方案很难使用。现在，借助SPRm 200，生物传感仪器为研究候选药物和细胞靶标提供了一种易于使用的解决方案。

“许多学术实验室一直在开发SPR系统，以获得更多关于膜蛋白的生物学相关结合信息，但自制解决方案很难使用。现在，借助SPRm 200，生物传感仪器为研究候选药物和细胞靶标提供了一种易于使用的解决方案，“BI研发总监Nguyen Ly博士说。“我们的合作者对新系统能够量化膜蛋白在其天然细胞环境中的结合亲和力和动力学以及进行不同细胞的异质性统计分析的能力感到非常兴奋。膜蛋白占目前药物靶标的一半以上，因此能够获得体外测量确实加快了药物和疫苗的开发。

SPRm 200 系统采用最先进的技术，无缝集成了光学成像和 SPR 技术，为研究人员提供了两者的优势。使用BI的新ImageSPR™软件，可以实时映射和量化每个细胞膜的结合亲和力和动力学反应。该系统的大光学视场和出色的SPR分辨率使研究人员能够测量单个细胞或多个细胞的局部结合活性和动力学。

SPRm 200 在设计时考虑了应用灵活性，还可用于测量病毒、细菌和纳米颗粒的纳米级结合活性。

要观看 SPRm 200 产品视频，请转到https://youtu.be/c4SrPzfOZNE.

关于生物传感仪器

生物传感仪器公司（BI）是2016年研发奖获得者，提供基于表面等离子体共振（SPR）的创新和高性能无标记分子相互作用分析仪器。BI SPR 仪器用于生命科学、药物发现、抗体表征、生物传感器和电化学应用，以测量生物分子的亲和力和动力学。

有关 BI 的其他信息，请访问www.biosensingusa.com.

Biosensing Instrument Introduces World’s First Commercially Available Surface Plasmon Resonance Microscopy System For Membrane Protein Interactions Research

Published: Feb 22, 2017

TEMPE, Ariz.--(BUSINESS WIRE)--Biosensing Instrument Inc (BI) introduced the SPRm 200, the world’s first commercially available surface plasmon resonance microscopy (SPRM) system. The new SPRm 200 is the only scientific solution on the market that enables label-free in vitro measurement of binding reactions and kinetics of individual cells in their native environment. By providing the ability to study molecular interactions using cells grown on the sensor chip, this novel system redefines the frontier of SPR technology. Researchers can now simply select a cell and directly perform binding affinity and kinetic studies all with one instrument.

“Many academic laboratories have been developing SPR systems to obtain more biologically relevant binding information about membrane proteins, but homemade solutions are difficult to use. Now, with the SPRm 200, Biosensing Instrument offers an easy-to-use solution for investigating drug candidates and cell targets”

“Many academic laboratories have been developing SPR systems to obtain more biologically relevant binding information about membrane proteins, but homemade solutions are difficult to use. Now, with the SPRm 200, Biosensing Instrument offers an easy-to-use solution for investigating drug candidates and cell targets,” said Dr. Nguyen Ly, Director of Research and Development at BI. “Our collaborators are very excited by the new system’s ability to quantify binding affinity and kinetics of membrane proteins in their native cellular environment and to perform heterogeneity statistical analysis of different cells. Membrane proteins account for more than half of present drug targets, so having access to in vitro measurement really expedites drug and vaccine development.”

The SPRm 200 system’s state-of-the-art technology seamlessly integrates optical imaging and SPR technology, affording researchers the benefits of both. Using BI’s new ImageSPR™ software, the binding affinity and kinetic responses of each cell membrane can be mapped and quantified in real-time. The system’s large optical field-of-view and excellent SPR resolution allows researchers to measure the local binding activities and kinetics of a single cell or multiple cells.

Engineered with application flexibility in mind, the SPRm 200 can also be utilized to measure the nanometer-scale binding activities of viruses, bacteria, and nanoparticles.

To watch the SPRm 200 product video, go to https://youtu.be/c4SrPzfOZNE.

About Biosensing Instrument

Biosensing Instrument Inc (BI), a 2016 R&D Award Winner, supplies innovative and high-performance label-free molecular interaction analysis instruments based on Surface Plasmon Resonance (SPR). BI SPR instruments are used in the life science, drug discovery, antibody characterization, biosensor, and electrochemistry applications to measure the affinity and kinetics of biomolecules.

Additional information about BI can be found at www.biosensingusa.com.

Biosensing Instrument, Inc.
Akemi Ueki, 480-491-2777
info2bi@biosensingusa.com