Albert J.R. Heck

Albert J.R. Heck (Utrecht University, The Netherlands) is scientific director of the Netherlands Proteomics Centre. Heck’s group emphasizes on the development and applications of advanced mass spectrometry-based proteomics technologies. Heck introduced TiO₂ and Ti⁴⁺-IMAC based technologies for phospho-enrichment. Heck pioneered the use of alternative proteases and hybrid peptide fragmentation techniques (e.g. EThcD, UVPD). His group also introduced ¹⁵N labeling in multicellular organisms and the cost-effective dimethyl labeling. Heck’s proteomics research focuses for a large part on cancer, stem cells and immunology. Besides the proteomics efforts, the group of Heck is also well known for its expertise in mass spectrometry based structural biology, using native mass spectrometry, cross-linking and/or HD exchange mass spectrometry. The Heck-lab developed dedicated instruments for the analysis of intact proteins and protein complexes, with most recently a new high-mass Orbitrap, a serious breakthrough for top-down proteomics and native mass spectrometry. Through the development of the XlinkX and PhoX workflows they also facilitated proteome wide cross-linking studies. In recent years he has also focused on analyzing biopharmaceuticals, and plasma glycoproteins and immunoglobulins.

Heck教授是荷兰蛋白质组学研究中心主任。Heck教授团队一直致力于基于质谱的先进蛋白质组学技术的开发和应用。Heck教授团队率先发展了基于TiO2和Ti4+-IMAC的蛋白质磷酸化修饰富集技术，同时也率先将多酶酶切和多种肽段碎裂技术(如EThcD, UVPD)应用于蛋白质组学研究。他的团队还在多细胞生物分析中中引入了15N标记和性价比更高的二甲基化标记技术。在蛋白质组学研究领域，Heck教授团队研究重心主要集中在癌症、干细胞和免疫学等方面。除了蛋白质组学方面的研究，Heck教授团队在基于质谱的结构生物学，包括天然质谱、交联质谱和氢氘交换质谱等方面也很多杰出的工作。Heck实验室开发的基于XlinkX和PhoX工作流程也极大促进了交联质谱技术在蛋白质结构和相互作用领域的应用。近年来，Heck实验室在生物制药、血浆糖蛋白和免疫球蛋白等领域也开展了相关工作和研究。