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高分辨表面增强拉曼光谱剖析血栓症机理
发布时间：
2016-09-25 18:35
来源：
HORIBA科学仪器事业部
| 领域： | 临床血液与检验学 | ||
| 样品： | 血栓 | 项目： | 反应监控 |
| 方案文件名 | 下载 |
|---|---|
高分辨表面增强拉曼光谱剖析血栓症机理 |
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ΑIIbβ3 is a key mediator in the thrombotic process and has been studied extensively. This current work reports the first Raman spectrum of the protein, and examines changes in conformation during activation. Using three common agonists (DTT, Mn(II) and EDTA), the results indicate that in each case activation is caused by reduction of disulfide links, but suggests that different disulfides are activated according to the reagent used. The histopathological correlation to these findings has yet to be determined.
