胰岛素信号通路PCR芯片Insulin Signaling Pathway PCR Array

                       胰岛素信号通路PCR芯片可检测与胰岛素反应有关的84个基因。芯片包含了与胰岛素受体有关的基因和胰岛素信号通路的靶基因，碳水化合物、脂类、蛋白代谢有关的基因和相关的生物学反应有关的基因也包括在内。此外，芯片还包含PI3K和MAPK信号通路的成员。通过实时定量PCR的方法，研究者即能够利用该芯片简单可靠地同时检测胰岛素反应相关的基因表达。
Insulin Receptor-Associated Proteins:
Insulin and Receptors: INS, INSL3, IRS1, IRS2, IRS4, SORBS1.
 Insulin-like Growth Factors and Receptors: IGF1R, IGF2, IGFBP1.
SH3/SH2 Adaptor Protein: CBL, GAB1, GRB2, IRS4, NCK1.
Other Genes Associated with Insulin Receptor Proteins: CAP1, DOK1, DOK2, DOK3, FRS2, FRS3, INSR, PDPK1, PPP1CA, PTPN1, PTPRF, SHC1. PI-3
Kinase Pathway: Components: AKT1, AKT2, AKT3, EIF2B1, EIF4EBP1, MTOR, GSK3A, GSK3B, PDPK1, PIK3CA, PIK3R1, PIK3R2, PRKCG, PRKCI, PRKCZ.
Target Genes: BCL2L1, DUSP14, G6PC, HK2, IGFBP1, PCK2, SERPINE1, SLC2A4, SREBF1, UCP1, VEGFA
MAPK Pathway:
Components: ARAF, BRAF, EIF2B1, GRB2, HRAS, MAP2K1, MAPK1, RAF1, RPS6KA1, RRAS, RRAS2, SHC1, SOS1. Target genes: ANG, BCL2L1, ERCC1, FOS, LDLR, NOS2, UCP1.
Primary Target Genes for Insulin Signaling: CEBPA, CEBPB, FOS, JUN, LEP, PRL.
 Secondary Effector Target Genes for Insulin Signaling: NPY, PCK2, SLC2A1, SLC2A4, TG. Target genes for PPARg: ACOX1, ADRB3, AEBP1, CAP1, CEBPA, CEBPB, PCK2, PPARG, RETN. Target genes for SREBP1: ACACA, FBP1, G6PC, GCK, PCK2, PKM2.
Carbohydrate Metabolism:
 Glucose Metabolism: FBP1, G6PC, GCK, HK2, INS, IRS2, PCK2, PKM2, SLC2A1, SLC2A4, SORBS1.
Glycogen Metabolism: G6PC, GSK3B, PPP1CA.
 Other Genes Related to Carbohydrate Metabolism: ADRB3, GPD1, INSR.
 Lipid Metabolism:
Cholesterol Metabolism:LDLR, SREBF1.
Fatty Acid Metabolism: ACACA, ACOX1, FASN.
 Lipid Transport: LDLR, SORBS1.
 Other Lipid Metabolism Genes: ARAF, BRAF, INS, LEP, PPARG, PRKCG, PRKCI, PRKCZ, RAF1, SHC1.
 Protein Metabolism:
 Protein Amino Acid Dephosphorylation: DUSP14, PPP1CA, PTPN1, PTPRF.
 Protein Amino Acid Phosphorylation: AKT1, AKT2, AKT3, ARAF, BRAF, GSK3A, GSK3B, IGF1R, INSL3, INSR, MAP2K1, MAPK1, PDPK1, PRKCG, PRKCI, PRKCZ, RAF1, RPS6KA1.
 Protein Biosynthesis: ANG, EIF2B1, EIF4EBP1, LDLR, PPP1CA.
 Protein Transport: PRKCI, RRAS2.
 Other Protein Metabolism Genes: AEBP1, CBL, DOK1, DOK2, FRS2, GAB1, IRS1, NOS2, SORBS1, VEGFA.
 Transcription Factors and Regulators:
 DNA-dependent Regulation of Transcription: CEBPA, CEBPB, FOS, JUN, PPARG, SREBF1.
 RNA Polymerase II Transcription Factor Activity: CEBPA, FOS, JUN, SREBF1.
 Transcription Factors: AEBP1, CBL, CEBPA, CEBPB, JUN, PPARG, SREBF1.
 Cell Growth and Differentiation:
 Cell Cycle: MTOR, HK2, HRAS, IGF1R, IGF2, KRAS, MAPK1, VEGFA.
Cell Proliferation: GAB1, IGF1R, IGF2, IRS2, NCK1, NPY, PRL, RAF1, SHC1, VEGFA.
 Growth Factors and Receptors: GAB1, GRB2, IGF1R, IGF2, IGFBP1, INSR, SHC1, VEGFA.
 Cell differentiation: NOS2, PPARG

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