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Polycomb & Trithorax Complexes PCR Array

Polycomb & Trithorax复合物PCR基因芯片
 

ProductSpeciesTechnologyCat. No.Polycomb & Trithorax Complexes PCR ArrayHumanGene ExpressionPAHS-506ZPolycomb & Trithorax Complexes PCR ArrayMouseGene ExpressionPAMM-506ZPolycomb & Trithorax Complexes PCR ArrayRatGene ExpressionPARN-506Z

Polycomb & Trithorax Complexes RT² Profiler™ PCR Array profiles the expression of 84 key polycomb and trithorax complex components including chromatin modification enzymes and remodeling factors. The polycomb and trithorax complexes maintain epigenetic control of cell type specific gene expression patterns important for cellular identity via histone modification. The polycomb complex causes transcriptional repression, while the trithorax complex reverses that effect to maintain an active state of transcription. Polycomb and trithorax complex activity controls the proper differentiation of induced and embryonic pluripotent stem cells. Dysregulation of their activities promotes oncogenesis by causing inappropriate expression of cell identity, differentiation and proliferation genes. Research into the expression and regulation of these complexes can help determine the underlying mechanisms of histone modification based regulation of gene expression during differentiation and oncogenesis. This array includes core components of the polycomb and trithorax complexes as well as key interactors and genes necessary for complex assembly. Using real-time PCR, your research study can easily and reliably analyze the expression of a focused panel of genes involved in polycomb and trithorax complex activity with this array.
Polycomb & Trithorax复合物PCR基因芯片可以同时检测与Polycomb & Trithorax复合物相关的84个重点基因的表达，其中包括重要的染色质修饰酶和重塑因子。Polycomb & Trithorax复合物通过组蛋白修饰参与表观遗传调控，是维持细胞特异性基因表达的重要机制。Polycomb复合体引起转录抑制；而Trithorax复合体行使反转效果，保持基因的积极转录。Polycomb & Trithorax复合物的活性控制着胚胎多能干细胞分化的机制的诱导。它们活性的失调造成细胞特性改变，细胞分化和增殖基因的错误表达，并促进肿瘤发生。关于这些复合物的表达与调控的研究可以帮助研究者确定在细胞分化和癌变过程中，基于组蛋白修饰的基因表达调控的基本机制。该芯片包括Polycomb & Trithorax复合物的核心组成基因和装配这些基因所必需的基因。利用实时定量PCR，研究者可以方便并且可信地研究对与polycomb的和Trithorax复合物相关的基因进行同时检测。
Polycomb Complexes:
Core Components:BMI1 (PCGF4), EED, EZH2, PHC1, PHC2, PHC3, RBBP4, RBBP7, RING1, RNASEL, SCMH1.
Alternate Core Components:CBX5, EZH1, PHF1, RNF2.
Additional Complex Components:CBX8, DNMT1, DNMT3A, DNMT3B, E2F6, KDM2B, KDM5D, PCGF1, PCGF2 (RNF110), PHC2, RING1, RNF2, RNF2, RYBP.
Polycomb Cofactors:
Complex Assembly:AEBP2, RBP2, SNAI1, ZBTB16.
Complex Interacting Genes:ARID1B, ASXL1, ASXL2, ASXL3, BAP1, CBX1, CBX2, CBX3, CBX4, CBX7, CTBP2, DNMT3L, EPC1, EPC2, HTT, INO80 (INOC1), INO80B, INO80C, INO80D, JARID2, L3MBTL2, LARP7, MBTD1, KMT2B, KMT2E, MOV10, MTF2, PCGF5, PHF19, PPP1CC, PPP1R8, SCML2, SIRT1, SMARCA4, SMARCC1, TRIM27, USP11, USP7, YAF2, YY1AP1, YY2.
Trithorax Complexes:
Core Components:ARID1A, ASH2L, CXXC1, HLTF, KMT2D, KMT2C, PBRM1, RBBP4, RBBP5, RBBP7, SMARCA1, SMARCA2, SMARCB1, SMARCC2, WDR5.
Complex Interacting Genes:ARID1B, KMT2B, SMARCA4, SMARCA5, SMARCC1.

 

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