Human Phagocytosis PCR Array The Human Phagocytosis RT2 Profiler PCR Array profiles the expression of 84 genes involved in phagocytosis - the process by which macrophages, dendritic cells, and other myeloid phagocytes internalize diverse particulate targets. In some cases, the innate immune cells take up and destroy pathogenic bacteria, apoptotic cells, and other large particles. In other cases, the peptide antigens from these particles are preserved for presentation in association with major histocompatibility complex (MHC) class I or class II molecules to stimulate antigen-specific T cells which destroy them. The molecular and cellular events that underlie the binding of targets to a phagocyte and their engulfment into phagosomes and processing in the phagosome have been extensively studied. The process of phagocytosis, in either case, provides information to myeloid phagocytes about the nature of the targets being engulfed and helps to tailor immune responses. The genes profiled with this array include receptors involved in phagocytosis, recognition and engulfment of particulate target, phagosome maturation, and signal transduction, as well as cytokines and chemokines to characterize the phagocytic process in a model system. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification and assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in phagocytosis with this array.
The RT² Profiler PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.    

Receptors Involved in Phagocytosis: AGER, CD14, CD36, CLEC7A, COLEC12, CR1, CRP, FAS, FCER1G, FCGR1A, FCGR2A, FCGR2B, IL1RL1, ITGAM, ITGAV, ITGB2, MARCO, MFGE8, MYD88, PECAM1, TICAM1, TLR3, TLR9.
Recognition and Engulfment: ANXA1, C3, CD44, CD47, CEACAM3, CSF1, CSF2, ELMO1, GULP1, IFNG, MBL2, MCOLN3, MIF, SCARB1, SIGLEC1, SIGLEC11, SIRPB1, TGM2, TNF, WNT5A.
Phagosome Maturation: CNN2, PLD1, RAB5A, RAB7A, STX18, VAMP7, WAS.
Phagosome processing: CALR, CRK, CYP2S1, NOD1, PLA2G4A, PLA2G5, PLD2, SERPINE1, SFTPD, STAB2, TNFSF11.
Signal Transduction: ADIPOQ, AXL, CLIC4, CSK, DOCK1, DOCK2, FYN, LYN, MAPK14, MERTK, MSN, PIP5K1A, PRKCE, PROS1, PTEN, RAC1, RAC2, RALA, RALB, RAPGEF3, RHOA, SYK, VAV1.

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