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药物和辅料的表面能测定
| 领域： | 原料药/中间体,化学药,药品包装材料/辅料 | ||
| 样品： | 乳糖，API | 项目： | 表面能 |
| 参考： | « Adsorption of n-alkanes at zero surface coverage on cellulose paper and wood fibers »; G. M. Dorris, D. G. Gray; Journal of Colloid and Interface Science 77(1980), 353-362. | ||
| 方案文件名 | 下载 |
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药物和辅料的表面能测定 |
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Key points
• The measurements are run simultaneously and independently on two columns filled with the same Lactose monohydrate
sample.
• All the molecular probes are injected at infinite dilution (ID) conditions, namely at zero surface coverage. The retention
times (tN) of several n-alkanes probes are measured.
• Only at ID conditions the adsorption energy (ΔGa) is directely related to tN by: ΔGa=R.T.Ln(tN.F)+ Cst [1]
with F the carrier flow rate, T the measurement temperature, R the gas constant and Cst a constant.
• The method proposed by Dorris and Gray is then applied in order to determine the dispersive component of the surface
energy ( γ sd ).
关键点：
. 单水乳糖为样品，同时在两根柱子中，同时测定
. 基于无限稀释条件下（ID）,表面零覆盖，测定不同类型直链烷烃分子的保留时间
. 基于Dorris-Gray 模型，计算表面能。
