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筛查、鉴定和定量分析潜在的遗传毒性化合物
| 领域： | 基因/基因组/测序 | ||
| 样品： | 遗传毒性 | 项目： | 分析潜在的遗传毒性化合物 |
| 参考： | - | ||
| 方案文件名 | 下载 |
|---|---|
筛查、鉴定和定量分析潜在的遗传毒性化合物 |
下载此篇方案 |
This study demonstrates a routine screening of drugs to identify and quantify
potential genotoxic compounds. In this Application Note, we used an Agilent 6545
Q
-
TOF LC/MS system to acquire accurate mass data of samples containing
chlorhexidine as the dr
ug substance. Agilent MassHunter Mass Profi ler
software was used to mine the data and compare different samples to generate
a differential list of compounds. An accurate mass database search against the
differential list identifi ed 4
-
chloroaniline, a
potential genotoxic compound. All
Ions
MS/MS acquisition mode was used to confi rm 4
-
chloroaniline by MS/MS library
matching, and quantify it using external standards. This workfl ow is suitable for
batch
-
to
-
batch sample analysis for detecting and quant
ifying known potential
genotoxic compounds
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