Zetasizer Ultra纳米粒度仪

Zetasizer Ultra 综合了全球功能最强大的 DLS 与 ELS 系统，它采用了非侵入背散射 (NIBS®) 和独特的多角动态光散射 (MADLS) 技术来测量颗粒与分子粒度。 NIBS 的多用性和灵敏度可测量广泛的浓度范围，而 MADLS 则能让您在这些关键测量当中更精细地了解样品粒度分布。

MADLS 的扩展能够直接分析颗粒浓度。 颗粒浓度的测量无需校准，适合于广泛的材料，无需或只需极少稀释，并且使用快捷，这一切都使其成为一种理想的筛选技术。  这是 Zetasizer Ultra 的一项独特功能，甚至可以运用于以前非常难测量的病毒和 VLP 等样品。 

Zetasizer Ultra 还利用 M3-PALS 技术提供了灵敏度极高的电动电势和电泳迁移率测量。  我们具有极高性价比的一次性折叠毛细管样品池允许使用我们的zl扩散障碍法在极低样品量的情况下进行测量，并且不会产生直接样品电极接触。  此类测量提供的信息可以极好地指出样品稳定性以及/或者聚集倾向。

增加的恒流模式可在高导电性介质中测量电泳迁移率和电动电势，从而减少由于较高离子浓度下的电极极化而出现的错误。

上市时间：2018年6月

马尔文帕纳科Zetasizer Pro/Ultra系统的ZS Xplorer软件，引入了新的样品中心流程概念，使得其方法设计和数据分析对新用户而言更为直接，同时保留了完整的对于光散射法应用的用户体验。新的分析功能首次回应了使用动态光散射法表征微粒和分子过程中存在的尘埃或团聚这一关键问题，通过从结果中滤除这些杂质的曲线来得到一个更真实的样品信息。通过集成的、深度学习的、授权的数据质量指导的支持，为用户测量结果提供即时反馈，以及对于低质量数据的改进提供可操作的建议。 马尔文帕纳科Zetasizer Ultra另一个与众不同之处是其zl的多角度动态光散射(MADLS®)技术，可以自动通过多角度进行检测，为待测样品提供了更高的分辨率和更完整的粒径分布信息。MADLS还可以分析不同粒径范围的颗粒浓度，可对大部分材料可进行无需校准的浓度分析。新的可抛弃性毛细管粒径检测池实现了无损检测，将低容量（3微升）分析的粒度上限扩展到了10微米，在降低成本的同时还可提高数据质量。通过这些独特而强大的功能，Zetasizer Ultra的速度和易用性是卓越超群的，使其成为目前业内最先进的光散射系统。

Zetasizer Ultra

Advance with Confidence

The new Zetasizer Ultra is our most advanced system for the measurement of particle and molecular size, particle charge and particle concentration, and represents the most intelligent and flexible instrument in the Zetasizer range. 

This flagship instrument enjoys all the benefits afforded by ZS Xplorer software, in terms of ease of use, analysis speed and data confidence, and also offers two unique measurement capabilities: Multi-Angle Dynamic Light Scattering (MADLS®) and Particle Concentration, to offer even greater insight into your samples.

概述：

The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS®) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size. NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution for those critical measurements.

An extension to MADLS affords the ability to directly analyze particle concentration. The measurement of particle concentration is calibration-free, suitable for a wide range of materials, requires no or little dilution, and is quick to use – all of which make it ideal as a screening technique.  This is a unique capability of the Zetasizer Ultra which can even be applied to samples such as viruses and VLPs, which were previously very challenging to measure. 

The Zetasizer Ultra also provides the highest sensitivity zeta potential and electrophoretic mobility measurements using M3-PALS technology.  Our affordable disposable folded capillary cells enable measurements in extremely low volumes, without direct sample-electrode contact, using our patented diffusion barrier method.  The information provided by these measurements is an excellent indicator of sample stability and/or propensity to aggregate.

The addition of Constant Current Mode for measuring electrophoretic mobility and zeta potential in high conductivity media reduces errors that can be associated with electrode polarization at higher ion concentrations.

原理：

The Zetasizer Ultra incorporates two technologies in a single compact unit, with a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering (DLS) is used to measure particle and molecule size. DLS measures the diffusion of particles moving under Brownian motion and converts this to particle size and particle size distribution using the Stokes-Einstein relationship. Non-Invasive Back-Scatter (NIBS) technology is incorporated to give the highest sensitivity within the broadest range of sizes and concentrations. DLS is a highly flexible sizing method which is rapid, accurate and repeatable. It requires only small volumes of sample for analysis, and is non-destructive. This technique is material-independent and therefore extremely widely applicable.

Multi-Angle Dynamic Light Scattering (MADLS) is also incorporated in the Zetasizer Ultra, to offer the highest resolution and angular-independent size distribution analysis. MADLS also enables the simple, calibration-free measurement of particle concentration in homogeneous sample types, covering a wide range of materials.

Electrophoretic Light Scattering (ELS) is used to measure zeta potential. An electric field is applied to a solution of molecules or a dispersion of particles which move with a velocity related to their charge. This velocity is measured using a patented laser interferometric technique called M3-PALS (Phase Analysis Light Scattering). This enables the calculation of electrophoretic mobility, and from this, the zeta potential and zeta potential distribution of a sample.

The use of ELS commonly relates to stability and formulation applications. Particles or molecules with no net charge may bind together, which may be a challenge in systems such as protein formulations which are prone to aggregation. Particles or molecules which have either a net positive or net negative charge will better maintain a distance from one another, creating a stable system. The formulation containing these particles or molecules is very influential on their charge state, and changes to formulation attributes such as pH, additive concentration and ionic concentration can impact product stability and shelf life.

ZS Xplorer Software Suite

The software is designed to be very easy to use, even whilst enabling the rapid construction of complex methods. Information on the sample, its conditions, and the variables to be tested are entered at the beginning of a run, and ZS Xplorer uses this information intelligently to optimize the method for that sample. A deep learning empowered data quality guidance system provides feedback on results and offers clear advice on how data may be improved if required.

Options

The MPT-3 Auto titrator enables study of the effect of changes in pH.

A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume and concentration, including the new low volume disposable sizing cell kit, which offers the dual benefits of size measurements in as little as 3uL, and extension to the upper size range of DLS measurements, due to the suppression of convection currents.

特点：

• Multi-Angle Dynamic Light Scattering (MADLS) scheme for absolute confidence in particle and molecular size distribution analysis

• NIBS optics for versatile, high sensitivity, particle and molecular size measurements

• Simple, calibration-free particle concentration measurements

• Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 µL) analysis, with an upper size range that extends to 10 μm

• M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements

• ZS Xplorer software suite for simple and flexible method set-up and data analysis

• Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation

• Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results

• Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.  Also includes polarization filters for DDLS measurements.

May 23 2018 - Ref No: PR180523

Malvern Panalytical has unveiled its new Zetasizer® Pro and Ultra systems, designed to increase confidence in decision-making within key analytical workflows associated with product development and quality control. Built on the heritage of the market-leading Zetasizer Nano range, and already the proud recipients of a Red Dot 2018 design award, these new flagship instruments deliver significant improvements in the quality and speed of particle size, molecule size and zeta potential measurements, using the techniques of dynamic and electrophoretic light scattering. 

Darrell Bancarz, Nanomaterials Product Manager at Malvern Panalytical, said, “The Zetasizer Pro and Zetasizer Ultra are the result of extensive customer understanding, research and testing, which has enabled us to develop a more intelligent and intuitive way of making light scattering measurements. We’ve introduced capabilities that halve sample preparation and measurement times, while providing more stable and reliable results. The application of revolutionary new measurement approaches delivers extended materials insight, enabling true product and process optimization.”

Pavel Abdulkin, Head of Particle Works, Blacktrace Holdings Ltd., which develops and manufactures high performance nanoparticles and microparticles, was clear about the impact of the new technology on his work: “The Zetasizer Ultra has dramatically increased our sample throughput, enabling us to accelerate our particle development cycle from 12 months to around a month.”

The Zetasizer Pro and Ultra systems are controlled by groundbreaking ZS Xplorer software, introducing new sample-centric workflows which make method design and data analysis more straightforward for new users, while preserving full accessibility for users experienced in the application of light scattering methods. New analysis capabilities answer, for the first time, key issues associated with the presence of dust or aggregates when applying dynamic light scattering for particle and molecular characterization, filtering these from the results to give a truer overall picture of the sample. This is supported by integrated, deep-learning empowered data quality guidance, offering the user instant feedback on their results and providing actionable advice on how to improve poor quality data.

A key differentiator of the Zetasizer Ultra is its patented Multi-Angle Dynamic Light Scattering (MADLS®) technology, which automates multiple-angle size measurements, providing higher resolution and more complete particle size distributions. MADLS also enables calibration-free particle concentration analysis for a wide range of materials, resolving the individual concentrations of different size populations. The new disposable capillary sizing cell provides the ultimate in non-destructive, low volume (3 μL) analysis, extending the upper range to 10 μm and delivering high quality data whilst reducing cost. The Zetasizer Ultra’s speed and ease-of-use are uncompromised by these unique and powerful capabilities, making it the most advanced light scattering system available.

Zetasizer systems are used across many industry sectors worldwide, delivering value in the control and optimization of processes, and the improvement of product quality, stability and performance. They are ubiquitous in academic settings, indispensable in a wealth of application spaces and referenced in tens of thousands of peer-reviewed publications.

For more information about the Zetasizer Pro and Zetasizer Ultra, contact Malvern Panalytical, or register for the launch webinar.