这个基因编码一个GTPase激活蛋白（GAP），它是rhoGAP家族的一个成员，在调节小GTP结合蛋白中起作用GAP家族蛋白参与调控细胞骨架变化过程的信号传导途径这种基因在许多常见的癌症中起着抑癌基因的作用，包括前列腺癌、肺癌、结直肠癌和乳腺癌。由于选择性启动子和选择性剪接，已经发现了该基因的多个转录变体。[由RefSeq提供，2010年4月]
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]