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CFLAR基因编码功能及结构描述

2022.8.09

该基因编码的蛋白是一种细胞凋亡调节因子,其结构与caspase-8相似。然而,编码蛋白缺乏半胱天冬酶活性,似乎自己被半胱天冬酶8分裂成两个肽。该基因有几种编码不同亚型的转录变体,并且存在更多变体的部分证据。

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists.

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