TSHZ3基因编码的功能和结构描述
该基因编码一种锌指转录因子，调控发育中尿路平滑肌细胞分化。与此作用一致的是，该基因被灭活的小鼠在尿路平滑肌细胞前体和肾缺损（包括肾积水）中表现出异常的基因表达编码的转录因子包含抑制caspase表达的基因沉默复合物。该基因的表达减少和caspase的上调可能与人类阿尔茨海默病的进展有关。
This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients.
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