CDC25B基因突变与药物因子介绍
cdc25b是cdc25磷酸酶家族的成员。CDC25B通过去除两个磷酸基团激活细胞周期蛋白依赖性激酶CDC2，它是有丝分裂所必需的cdc25b在细胞核和细胞质之间穿梭是由于细胞核定位和核输出信号。该蛋白在细胞周期的M期和G1期是细胞核，在S期和G2期移向细胞质CDC25B具有致癌特性，但其在肿瘤形成中的作用尚未确定该基因的多个转录变体存在。[由RefSeq提供，2008年7月]
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]
