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与免疫相关信号通路相关因子介绍--IKBKE

2022.7.20

ikbke是一种非特异性的i-kappa-b激酶(见mim 164008),对调节抗病毒信号通路至关重要。ikbke也被确定为乳腺癌(mim 114480)癌基因,在超过30%的乳腺癌和乳腺癌细胞系中被扩增和过度表达(hutti等人,2009年[pubmed 19481526])。[由omim提供,2009年10月]
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

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