该基因属于t-box基因家族，编码一个系统发育保守的转录因子家族，调控多种发育过程。所有这些基因都含有一个共同的T盒DNA结合域该基因突变与表亲综合征有关。

This gene belongs to the T-box family of genes, which encode a phylogenetically conserved family of transcription factors that regulate a variety of developmental processes. All these genes contain a common T-box DNA-binding domain. Mutations in this gene are associated with Cousin syndrome.