PASK基因编码的功能和结构描述
该基因编码丝氨酸/苏氨酸激酶家族的一个成员,该家族包含两个PAS结构域该基因的表达受葡萄糖调节,编码蛋白在胰岛素基因表达调控中起作用这种基因的下调可能在2型糖尿病中起作用。另外,已经观察到该基因编码多个亚型的剪接转录变体。
This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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