IL6ST基因编码功能及结构描述
该基因编码的蛋白是多种细胞因子共有的信号转导子，包括白细胞介素6（il6）、睫状神经营养因子（cntf）、白血病抑制因子（lif）和肿瘤抑制素m（osm）。这种蛋白质是细胞因子受体复合体的一部分。这种蛋白的激活依赖于细胞因子与其受体的结合。vil6是一种与il6相关的蛋白，由kaposi肉瘤相关疱疹病毒编码，可以绕过白细胞介素6受体（il6r）直接激活该蛋白。小鼠的基因敲除研究表明，该基因在调节心肌细胞凋亡中起着关键作用。另外，已经描述了剪接转录变体。在17号染色体上发现了一个相关的假基因。[由RefSeq提供，2014年5月]
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]
