UBR5基因编码的功能和结构描述
该基因编码孕激素诱导蛋白，属于HECT（与E6-AP羧基末端同源）家族hect家族蛋白作为e3泛素蛋白连接酶发挥作用，靶向泛素介导的蛋白水解的特异性蛋白。该基因定位于染色体8q22，在多种癌症中被破坏。这个基因可能在细胞增殖或分化的调节中起作用。
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
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