MicroRNA Expression Profiling by Bead Array -3
Table 2 Modulation of microRNA expression by IFNα—4 and 24 h after stimulation
Control | Interferon-alpha treated | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
4 h | 24 h | 4 h | 24 h | |||||||||||
a | ME-15 | HuH7 | CHF | ME-15 | HuH7 | CHF | ME-15 | HuH7 | CHF | ME-15 | HuH7 | CHF | ||
Validated microRNAs | ||||||||||||||
hsa-miR-19a | 13,617 | 6,726 | −1.02 | 18,318 | 17,178 | −0.07 | 19,226 | 17,409 | −0.10 | 14,425 | 14,079 | −0.02 | ||
hsa-miR-19b | 13,365 | 9,406 | −0.42 | 25,463 | 22,438 | −0.13 | 21,532 | 20,625 | −0.04 | 18,039 | 17,440 | −0.03 | ||
hsa-miR-30e-5p | 9,497 | 6,838 | −0.39 | 13,045 | 11,321 | −0.15 | 12,643 | 10,887 | −0.16 | 13,230 | 11,809 | −0.12 | ||
hsa-let-7a | 15,244 | 4,335 | −2.52. | 28,304 | 6,181 | −3.58 *** | 22,226 | 6,386 | −2.48*** | 30,449 | 5,612 | −4.43*** | ||
hsa-let-7b | 8,236 | 539 | −14.28*** | 12,563 | 475 | −25.44*** | 12,150 | 500 | −23.30 *** | 12,309 | 452 | −26.24*** | ||
hsa-miR-203 | 907 | 325 | −1.79** | 1,155 | 348 | 2.32*** | 1,302 | 359 | −2.63*** | 1,186 | 5,757 | −1.07** | ||
hsa-miR-130b | 5,700 | 8,316 | −0.46 | 13,023 | 13,880 | 0.07 | 9,994 | 14,055 | 0.41 | 12,053 | 12,432 | 0.03 | ||
hsa-miR-455 | 2,677 | 2,604 | −0.03 | 3,944 | 5,285 | 0.34* | 3,437 | 5,927 | 0.72** | 3,262 | 5,342 | 0.64* | ||
b | ME-15 | HuH7 | ||||||||||||
4 h | 24 h | 4 h | 24 h | |||||||||||
−IFNa | +IFNa | CHF | −IFNa | +IFNa | CHF | −IFNa | +IFNa | CHF | −IFNa | +IFNa | CHF | |||
Interferon-regulated microRNAs | ||||||||||||||
hsa-miR-33b | 1,226 | 3,484 | 1.84** | 2,888 | 2,318 | −0.25 | 476 | 1,113 | 1.34** | 1,306 | 1,851 | 0.42*** | ||
hsa-miR-33 | 2,631 | 7,352 | 1.79 | 9,774 | 5,764 | −0.70* | 1,887 | 6,645 | 2.52. | 8,893 | 2,726 | −2.26 | ||
hsa-miR-126* | 2,221 | 5,409 | 1.44* | 5,578 | 6,111 | 0.10 | 4,749 | 6,410 | 0.35. | 5,687 | 5,803 | 0.02*** | ||
hsa-miR-10b | 1,695 | 3,564 | 1.10* | 2,929 | 4,297 | 0.47** | 378 | 411 | 0.09 | 371 | 382 | 0.03 | ||
hsa-miR-551b | 2,085 | 4,169 | 1.00* | 4,423 | 3,419 | −0.29 | 1,804 | 4,979 | 1.76* | 5,221 | 4,865 | −0.07 | ||
hsa-miR-137 | 1,037 | 1,966 | 0.90 | 2,523 | 2,872 | 0.14 | 1,613 | 3,155 | 0.96** | 3,429 | 3,598 | 0.05 | ||
hsa-miR-138 | 2,158 | 4,074 | 0.89* | 4,709 | 3,701 | −0.27 | 725 | 828 | 0.14 | 903 | 859 | −0.05 | ||
hsa-miR-130b | 5,700 | 9,994 | 0.75 | 13,023 | 12,053 | −0.08 | 8,316 | 14,055 | 0.69** | 13,880 | 12,432 | −0.12 | ||
hsa-miR-101 | 6,701 | 11,387 | 0.70 | 13,088 | 11,688 | −0.12 | 3,569 | 10,871 | 2.05** | 10,445 | 10,796 | 0.03 | ||
hsa-miR-140 | 7,339 | 12,236 | 0.67 | 15,512 | 15,931 | 0.03 | 3,058 | 5,976 | 0.95* | 6,135 | 7,221 | 0.18 | ||
HS_92 | 829 | 1,356 | 0.64. |
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