实体肿瘤检测RAD51B基因介绍
这个基因编码的蛋白质是rad51蛋白家族的一员。rad51家族成员是进化上保守的蛋白质，通过同源重组修复dna。该蛋白已被证明与家族成员rad51c形成稳定的异二聚体，该异二聚体进一步与其他家族成员（如rad51、xrcc2和xrcc3）相互作用。该基因的过度表达导致细胞周期g1延迟和细胞凋亡，提示该蛋白在检测dna损伤中的作用。在子宫肌瘤中观察到该位点与钩2处高迁移率群（hmga2，geneid 8091）之间的重排。
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata.
