TCF7L2基因编码的功能和结构描述
该基因编码一个高迁移率族（hmg）盒，包含在wnt信号通路中起关键作用的转录因子。这种蛋白质与血糖稳态有关。这种基因的遗传变异与2型糖尿病风险增加有关。已经发现了该基因编码多种不同亚型的转录变体。
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
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