CDH5基因突变与药物因子介绍
这个基因编码钙粘蛋白超家族的一个成员。钙粘蛋白是一类膜糖蛋白，介导细胞与细胞间的粘附，在细胞分化和形态发生中起重要作用。编码蛋白是一种II型钙黏蛋白，可能在肾脏发育以及子宫内膜和胎盘形成中发挥作用该基因的表达降低可能与肿瘤的生长和转移有关[由RefSeq提供，2011年5月]
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
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